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Differences of FENO in adult general populations of Nordic regions
Unit of Clinical Physiology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology and Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Örebro University, School of Medical Sciences. Örebro University Hospital. University of Lund, Lund, Sweden.ORCID iD: 0000-0003-4164-6513
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, no Suppl. 63Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Eventual differences of expiratory nitric oxide (FENO) levels in general populations of Nordic countries may reflect differences in eosinophilic inflammation at population level.

Aim: To study the differences in FENO of Nordic regions and their epidemiological associations.

Methods: From 1997 to 2003 we measured FENO (ppb) and conducted skin prick-tests for a random sample of adults (n=1498), aged 20-60 years from Finland (Helsinki), Sweden (Stockholm and Örebro) and Estonia (Narva and Saaremaa). We compared differences between regions by estimating odds ratios (OR) and 95% confidence intervals (CIs) for high FENO (>25 ppb) using logistic regression adjusted for gender, smoking and allergy. Finally, we estimated crude ORs and 95% CIs for high FENO and for asthma, rhinitis, current asthma symptoms and asthma medication.

Results: The mean and standard deviation (SD) for FENO was 19(14) in Finland, 18(12) in Sweden and 16(15) in Estonia (p<0.001). Estonia had a lower mean FENO than other countries, with no differences between Finland and Sweden. Compared to Helsinki, the adjusted OR (95%CI) for high FENO was 0.42(0.21-0.81) in Stockholm, 0.65(0.43-0.98) in Örebro, 0.53(0.32-0.84) in Narva and 0.45(0.28-0.71) in Saaremaa. In Estonia, high FENO was associated with asthma, allergy, rhinitis, current asthma, and asthma medication; in Finland with rhinitis and use of short acting β-agonist; in Sweden with asthma and asthma medication. Smoking was associated with low FENO. Mean FENO in asthmatics was 24(19) in Finland, 20(12) in Sweden, and 43(49) in Estonia (p=0.07).

Conclusions: We observed a higher mean FENO in Finland and Sweden compared to Estonia, and found no overall differences of FENO levels in asthmatics.

Place, publisher, year, edition, pages
European Respiratory Society , 2019. Vol. 54, no Suppl. 63
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:oru:diva-79826DOI: 10.1183/13993003.congress-2019.PA5064ISI: 000507372406418OAI: oai:DiVA.org:oru-79826DiVA, id: diva2:1392112
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, Spain, September 28 - October 2, 2019
Available from: 2020-02-06 Created: 2020-02-06 Last updated: 2020-02-06Bibliographically approved

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