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Bleeding risk in breast cancer patients during concomitant administration of warfarin and tamoxifen: A population-based nested case-control study
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Oncology.ORCID iD: 0000-0001-6059-0194
Regional Cancer Center Uppsala-Örebro, Uppsala, Sweden; Translational Oncology & Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
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2020 (English)In: The Breast Journal, ISSN 1075-122X, E-ISSN 1524-4741Article in journal (Refereed) Epub ahead of print
Abstract [en]

We aimed to investigate whether the concomitant use of tamoxifen with warfarin is associated with higher risk for bleeding among patients with early estrogen-receptor (ER)-positive breast in a population-based nested case-control study. We identified 1787 patients taking warfarin and 92 cases hospitalized for bleeding and found an adjusted odds ratio (OR) of 1.42 (95% confidence interval (CI): 0.84-2.40) for the risk of bleeding in patients treated with warfarin that initiated tamoxifen within the previous 30 days. As a result, we could not definitively rule out a potential association between tamoxifen use during warfarin and bleeding risk in patients with breast cancer.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2020.
Keywords [en]
bleeding, breast cancer, tamoxifen, warfarin
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-79785DOI: 10.1111/tbj.13759ISI: 000509541200001PubMedID: 31989762OAI: oai:DiVA.org:oru-79785DiVA, id: diva2:1391933
Available from: 2020-02-05 Created: 2020-02-05 Last updated: 2020-02-06Bibliographically approved

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