Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
In vivo instability of 177Lu-DOTATATE during peptide receptor radionuclide therapy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
Show others and affiliations
2020 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, article id jnumed.119.237818Article in journal (Refereed) Epub ahead of print
Abstract [en]

Peptide receptor radiotherapy using 177Lu-labeled somatostatin ligand analogs is a well-established treatment for neuroendocrine tumors (NET), with 177Lu-DOTATATE having acquired marketing authorization in Europe and the USA. The investigation of the pharmacokinetics of those radiopharmaceuticals in vivo in humans is crucial for personalized treatment management and understanding of treatment effects. It requires input data on the in vivo stability of the radiopharmaceuticals in blood and plasma. The work presented here is devoted to the investigation of in vivo stability of 177Lu-DOTATATE in humans affected by NET. Unexpectedly, fast metabolism of the radiopharmaceutical was observed, with fraction of intact 177Lu-DOTATATE in plasma decreasing rapidly to 23±5% (mean ± SD) at 24 h and 1.7±0.9% at 96 h after injection.

Place, publisher, year, edition, pages
2020. article id jnumed.119.237818
Keywords [en]
177Lu-DOTATATE, Lutathera, Neuroendocrine, Radionuclide Therapy, Radiopharmaceuticals, dosimetry, metabolism, peptide receptor radionuclide therapy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-403857DOI: 10.2967/jnumed.119.237818PubMedID: 32005767OAI: oai:DiVA.org:uu-403857DiVA, id: diva2:1391711
Available from: 2020-02-05 Created: 2020-02-05 Last updated: 2020-02-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lubberink, MarkIlan, EzgiSandström, MattiasAndersson, CamillaVelikyan, IrinaSundin, Anders
By organisation
Radiology
In the same journal
Journal of Nuclear Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 25 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf