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InfleCS: Clustering Free Energy Landscapes with Gaussian Mixtures.
KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-2288-5711
KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-0828-3899
2019 (English)In: Journal of Chemical Theory and Computation, ISSN 1549-9618, E-ISSN 1549-9626, Vol. 15, no 12, p. 6752-6759Article in journal (Refereed) Published
Abstract [en]

Free energy landscapes provide insights into conformational ensembles of biomolecules. In order to analyze these landscapes and elucidate mechanisms underlying conformational changes, there is a need to extract metastable states with limited noise. This has remained a formidable task, despite a plethora of existing clustering methods. We present InfleCS, a novel method for extracting well-defined core states from free energy landscapes. The method is based on a Gaussian mixture free energy estimator and exploits the shape of the estimated density landscape. The core states that naturally arise from the clustering allow for detailed characterization of the conformational ensemble. The clustering quality is evaluated on three toy models with different properties, where the method is shown to consistently outperform other conventional and state-of-the-art clustering methods. Finally, the method is applied to a temperature enhanced molecular dynamics simulation of Ca2+-bound Calmodulin. Through the free energy landscape, we discover a pathway between a canonical and a compact state, revealing conformational changes driven by electrostatic interactions.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2019. Vol. 15, no 12, p. 6752-6759
National Category
Biophysics
Identifiers
URN: urn:nbn:se:kth:diva-267237DOI: 10.1021/acs.jctc.9b00454ISI: 000502688500019PubMedID: 31647864Scopus ID: 2-s2.0-85074906633OAI: oai:DiVA.org:kth-267237DiVA, id: diva2:1391567
Note

QC 20200205

Available from: 2020-02-05 Created: 2020-02-05 Last updated: 2020-02-05Bibliographically approved

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Westerlund, Annie M.Delemotte, Lucie
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CiteExportLink to record
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