Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Pre-traumatic conditions can influence cortisol levels before and after a brain injury
Sodra Alvsborg Hosp, Sweden; Uddevalla Cent Hosp, Sweden; Univ Gothenburg, Sweden.
Sahlgrens Univ Hosp, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.ORCID iD: 0000-0003-0756-7723
Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden.
Show others and affiliations
2020 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404Article in journal (Refereed) Epub ahead of print
Abstract [en]

Objective Satisfactory anabolic reactions, including the activation of the hypothalamic-pituitary-adrenal (HPA) axis, are essential following severe traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH). Many factors may influence this activation. This study aimed to investigate whether individuals who reported chronic diseases, psychosocial afflictions, or stressful events before a severe brain injury display a different pattern regarding cortisol levels retrospectively and up to three months compared with those who did not report stressful experiences. Materials and Methods Fifty-five patients aged 16-68 years who were admitted to the neurointensive care unit (NICU) were included. Hair cortisol measurements offer a unique opportunity to monitor cortisol levels retrospectively and after the trauma. Hair strands were collected as soon as possible after admission to the NICU and every month until three months after the injury/insult. The participants/relatives were asked about stressful events, psychosocial afflictions and recent and chronic diseases. Results The group who reported chronic diseases and/or stressful events before the brain injury had more than twice as high median hair cortisol levels before the brain injury compared with those who did not report stress, but the difference was not statistically significant (P = .12). Those who reported stress before the brain injury had statistically significantly lower hair cortisol values after the brain injury and they remained until three months after the injury. Conclusions Stressful events and/or chronic disease before brain injury might affect mobilization of adequate stress reactions following the trauma. However, the large variability in cortisol levels in these patients does not allow firm conclusions and more studies are needed.

Place, publisher, year, edition, pages
WILEY , 2020.
Keywords [en]
hair cortisol; pretraumatic conditions; severe brain injury; stress
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-163399DOI: 10.1111/ane.13212ISI: 000506255100001PubMedID: 31879940OAI: oai:DiVA.org:liu-163399DiVA, id: diva2:1391410
Note

Funding Agencies|Health and Medical Care Committee of Region Vastra Gotaland; Department of Research and Development-NU Hospital Organization, Region Vastra Gotaland; Department of Research Sodra Alvsborg Hospital; Sodra Alvsborg Research Council, Region Vastra Gotaland, Sweden

Available from: 2020-02-04 Created: 2020-02-04 Last updated: 2020-02-04

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Theodorsson, Elvar
By organisation
Division of Clinical ChemistryFaculty of Medicine and Health SciencesDepartment of Clinical Chemistry
In the same journal
Acta Neurologica Scandinavica
Neurology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf