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Extracellular Photovoltage Clamp Using Conducting Polymer-Modified Organic Photocapacitors
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering. Vilnius Univ, Lithuania.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
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2020 (English)In: ADVANCED MATERIALS TECHNOLOGIES, ISSN 2365-709X, article id 1900860Article in journal (Refereed) Epub ahead of print
Abstract [en]

Optoelectronic control of physiological processes accounts for new possibilities ranging from fundamental research to treatment of disease. Among nongenetic light-driven approaches, organic semiconductor-based device platforms such as the organic electrolytic photocapacitor (OEPC) offer the possibility of localized and wireless stimulation with a minimal mechanical footprint. Optimization of efficiency hinges on increasing effective capacitive charge delivery. Herein, a simple strategy to significantly enhance the photostimulation performance of OEPC devices by employing coatings of the conducting polymer formulation poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate), or PEDOT:PSS is reported. This modification increases the charge density of the stimulating photoelectrodes by a factor of 2-3 and simultaneously decreases the interfacial impedance. The electrophysiological effects of PEDOT:PSS-derivatized OEPCs on Xenopus laevis oocyte cells on membrane potential are measured and voltage-clamp techniques are used, finding an at-least twofold increase in capacitive coupling. The large electrolytic capacitance of PEDOT:PSS allows the OEPC to locally alter the extracellular voltage and keep it constant for long periods of time, effectively enabling a unique type of light-controlled membrane depolarization for measurements of ion channel opening. The finding that PEDOT:PSS-coated OEPCs can remain stable after a 50-day accelerated ageing test demonstrates that PEDOT:PSS modification can be applied for fabricating reliable and efficient optoelectronic stimulation devices.

Place, publisher, year, edition, pages
WILEY , 2020. article id 1900860
Keywords [en]
cellular photostimulation; electrophysiology; organic bioelectronics; organic photovoltaics; PEDOT; PSS
National Category
Condensed Matter Physics
Identifiers
URN: urn:nbn:se:liu:diva-163411DOI: 10.1002/admt.201900860ISI: 000507569600001OAI: oai:DiVA.org:liu-163411DiVA, id: diva2:1391390
Note

Funding Agencies|Knut and Alice Wallenberg Foundation within Linkoping University; Swedish Research Council (Vetenskapsradet)Swedish Research Council [2018-04505]; Swedish Foundation for Strategic Research (SSF)Swedish Foundation for Strategic Research

Available from: 2020-02-04 Created: 2020-02-04 Last updated: 2020-02-04

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Silverå Ejneby, MalinMigliaccio, LudovicoGicevicius, MindaugasDerek, VedranJakesova, MarieElinder, FredrikGlowacki, Eric
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Laboratory of Organic ElectronicsFaculty of Science & EngineeringPhysics and ElectronicsDivision of NeurobiologyFaculty of Medicine and Health Sciences
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