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The genomic footprint of sexual conflict
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution.ORCID iD: 0000-0001-5064-2093
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.ORCID iD: 0000-0003-1121-6950
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-6629-0173
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2019 (English)In: Nature Ecology & Evolution, E-ISSN 2397-334X, Vol. 3, no 12, p. 1725-1730Article in journal (Refereed) Published
Abstract [en]

Genes with sex-biased expression show a number of unique properties and this has been seen as evidence for conflicting selection pressures in males and females, forming a genetic 'tug-of-war' between the sexes. However, we lack studies of taxa where an understanding of conflicting phenotypic selection in the sexes has been linked with studies of genomic signatures of sexual conflict. Here, we provide such a link. We used an insect where sexual conflict is unusually well understood, the seed beetle Callosobruchus maculatus, to test for molecular genetic signals of sexual conflict across genes with varying degrees of sex-bias in expression. We sequenced, assembled and annotated its genome and performed population resequencing of three divergent populations. Sex-biased genes showed increased levels of genetic diversity and bore a remarkably clear footprint of relaxed purifying selection. Yet, segregating genetic variation was also affected by balancing selection in weakly female-biased genes, while male-biased genes showed signs of overall purifying selection. Female-biased genes contributed disproportionally to shared polymorphism across populations, while male-biased genes, male seminal fluid protein genes and sex-linked genes did not. Genes showing genomic signatures consistent with sexual conflict generally matched life-history phenotypes known to experience sexually antagonistic selection in this species. Our results highlight metabolic and reproductive processes, confirming the key role of general life-history traits in sexual conflict.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 3, no 12, p. 1725-1730
National Category
Genetics Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-402373DOI: 10.1038/s41559-019-1041-9ISI: 000500728800022PubMedID: 31740847OAI: oai:DiVA.org:uu-402373DiVA, id: diva2:1391133
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationEU, European Research Council, GENCON AdG-294333Swedish Research Council, 621-2014-4523Swedish Research Council Formas, 2018-00705Available from: 2020-02-03 Created: 2020-02-03 Last updated: 2020-02-03Bibliographically approved

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Sayadi, AhmedMartínez Barrio, ÁlvaroImmonen, ElinaDainat, JacquesBerger, DavidTellgren-Roth, ChristianNystedt, BjörnArnqvist, Göran
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Animal ecologyScience for Life Laboratory, SciLifeLabMolecular EvolutionEvolutionary BiologyDepartment of Medical Biochemistry and MicrobiologyDepartment of Immunology, Genetics and Pathology
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