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Low concentrations of the benzodiazepine drug oxazepam induce anxiolytic effects in wild-caught but not in laboratory zebrafish
Umeå University, Faculty of Science and Technology, Department of Chemistry. Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies, Umeå, Sweden; University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25 Vodňany, Czech Republic.ORCID iD: 0000-0003-1491-309X
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2020 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 703, article id 134701Article in journal (Refereed) Published
Abstract [en]

Pollution by psychoactive pharmaceuticals has been found to disrupt anti-predator behaviors of wild fish. The challenge is now to identify which of the many psychoactive drugs pose the greatest threat. One strategy is to screen for behavioral effects of selected pharmaceuticals using a single, widely available fish species such as zebrafish. Here, we show that although such high-throughput behavioral screening might facilitate comparisons between pharmaceuticals, the choice of strain is essential. While wild-caught zebrafish exposed to concentrations of the anxiolytic drug oxazepam as low as 0.57 μg L−1 showed a reduction in the response to conspecific alarm pheromone, laboratory strain AB did not respond to the alarm cue, and consequently, the anxiolytic effect of oxazepam could not be measured. Adaptation to the laboratory environment may have rendered laboratory strains unfit for use in some ecotoxicological and pharmacological studies, since the results might not translate to wild fish populations.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 703, article id 134701
Keywords [en]
Oxazepam, Benzodiazepines, GABA, Pharmaceutical pollution, Schreckstoff, Domestication
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:umu:diva-167632DOI: 10.1016/j.scitotenv.2019.134701ISI: 000505924300102PubMedID: 31734507Scopus ID: 2-s2.0-85074887580OAI: oai:DiVA.org:umu-167632DiVA, id: diva2:1391084
Available from: 2020-02-03 Created: 2020-02-03 Last updated: 2020-02-03Bibliographically approved

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