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Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first-degree relatives
Linköping University, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection. Linköping University, Faculty of Medicine and Health Sciences. Uppsala Univ, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection. Linköping University, Faculty of Medicine and Health Sciences. Uppsala Univ, Sweden.
Umea Univ, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection. Linköping University, Faculty of Medicine and Health Sciences.
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2020 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 199, no 2, p. 143-149Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to evaluate secretory antibodies to citrullinated proteins (ACPA) in plasma and immunoglobulin (Ig)A ACPA in saliva from patients with rheumatoid arthritis (RA) and their unaffected first-degree relatives (FDRs). Patients with RA (n = 194) and first-degree relatives unaffected by RA (n = 191) were recruited for analysis of secretory antibodies to second-generation cyclic citrullinated peptides (anti-CCP) in plasma. From a subpopulation (25 RA patients, 21 first-degree relatives and 11 controls), saliva samples were obtained for IgA anti-CCP analysis. The presence of secretory ACPA was compared between subject categories, and related to genetic and environmental risk factors. Secretory ACPA occurred in 37 (19%) plasma samples from patients with RA, but only in two (1%) of FDRs. IgA ACPA in saliva was found in three of 25 (12%) patients with RA, but not in any of the 21 FDRs (amp;lt; 5%). No significant associations were seen between the presence of secretory ACPA and SE or smoking, either among RA patients or among FDRs. Despite occurring in 19% of RA plasma, secretory ACPA was rare in both saliva and plasma among FDRs, even among those positive for conventional ACPA of non-mucosal origin. Longitudinal studies are warranted to determine whether circulating secretory ACPA occurs before or in parallel with the development of clinical arthritis.

Place, publisher, year, edition, pages
WILEY , 2020. Vol. 199, no 2, p. 143-149
Keywords [en]
ACPA; mucosa; relatives; rheumatoid arthritis; secretory immunoglobulin
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:liu:diva-163219DOI: 10.1111/cei.13381ISI: 000506542200004PubMedID: 31605388OAI: oai:DiVA.org:liu-163219DiVA, id: diva2:1390998
Note

Funding Agencies|the Swedish Research CouncilSwedish Research Council [K2013-52X-20307-07-03]; the Vasterbotten county council; Centrum for Klinisk Forskning Dalarna; the Ostergotland County Council; the Swedish Rheumatism Association; the Swedish Medical Society; King Gustaf Vs 80-Year Fund

Available from: 2020-02-03 Created: 2020-02-03 Last updated: 2020-02-03

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Svärd, AnnaRoos, KarinMartinsson, KlaraSjöwall, ChristopherKastbom, Alf
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Division of Inflammation and InfectionFaculty of Medicine and Health SciencesDepartment of Rheumatology
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