Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Terpene-enhanced transdermal permeation of water and ethanol in human epidermis.
National Defense Research Establishment, Department of NBC Defence, Division of Biomedicine and Department of Neurosurgery, University Hospital of Northern Sween, Umeå, Sweden.
1997 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 77, no 4, p. 264-267Article in journal (Refereed) Published
Abstract [en]

The study was performed to investigate the effect of penetration enhancers on the stratum corneum barrier. Epidermal membranes were prepared from freeze-stored (-70 degrees C) Caucasian breast skin and mounted in a flow-through diffusion cell. The validity of the freeze storage procedure was verified by measurement of [3H]-water penetration. The effect of the cyclic terpene, carveol, on the transdermal penetration of water and ethanol was studied in vitro. Control ethanol and water penetration measured with a donor solution of 50% ethanol/PBS (w/w) was 1.9+/-0.2 and 3.6+/-0.5 x 10(-3) cm/h. The addition of 3% carveol to the donor solution increased the permeation of ethanol and water after 4 h to 8.3+/-1.1 and 12.5+/-1.9 x 10(-3) cm/h, respectively. In a separate experiment, terpinen-4-ol and alpha-terpineol were also tested, in addition to carveol, for effect on tritium flux. No significant difference in maximum tritium flux was obtained between the three terpenes studied. The maximum increase in permeability coefficients of carveol, terpinen-4-ol and alpha-terpineol was 10.6, 8.7 and 10.9, respectively.

Place, publisher, year, edition, pages
1997. Vol. 77, no 4, p. 264-267
National Category
Physiology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-167535DOI: 10.2340/0001555577264267ISI: A1997XG21000003PubMedID: 9228215OAI: oai:DiVA.org:umu-167535DiVA, id: diva2:1388096
Available from: 2020-01-23 Created: 2020-01-23 Last updated: 2020-01-24Bibliographically approved

Open Access in DiVA

fulltext(4394 kB)5 downloads
File information
File name FULLTEXT01.pdfFile size 4394 kBChecksum SHA-512
c25bbafc11bf042afb01503b5070ff03fe3740e4894c6aacd723ce559963c355e511bf1346cc1a69925240d53a7eb3ed2c67fbe0a3a7bdf515a1dd849d407a4d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Koskinen, Lars-Owe D.
In the same journal
Acta Dermato-Venereologica
PhysiologyPharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
Total: 5 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 6 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf