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Evolution of Genomic Base Composition: From Single Cell Microbes to Multicellular Animals
Norwegian Inst Publ Hlth, Dept Infect Dis Epidemiol & Modelling, Div Infect Control & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway;Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, POB 222 Skoyen, N-0213 Oslo, Norway;Norwegian Univ Life Sci, Fac Vet Sci, Prod Anim Clin Sci, Ullevalsveien 72, N-0454 Oslo, Norway.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Univ Sydney, Sch Life & Environm Sci, Charles Perkins Ctr, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Publ Hlth Agcy Sweden, Nobels Vg 18, SE-17182 Solna, Sweden. (Zoonosis Science Centre)ORCID iD: 0000-0001-6665-7492
2019 (English)In: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, ISSN 2001-0370, Vol. 17, p. 362-370Article, review/survey (Refereed) Published
Abstract [en]

Whole genome sequencing (WGS) of thousands of microbial genomes has provided considerable insight into evolutionary mechanisms in the microbial world. While substantially fewer eukaryotic genomes are available for analyses the number is rapidly increasing. This mini-review summarizes broadly evolutionary dynamics of base composition in the different domains of life from the perspective of prokaryotes. Common and different evolutionary mechanisms influencing genomic base composition in eukaryotes and prokaryotes are discussed. The conclusion from the data currently available suggests that while there are similarities there are also striking differences in how genomic base composition has evolved within prokaryotes and eukaryotes. For instance, homologous recombination appears to increase GC content locally in eukaryotes due to a non-selective process termed GC-biased gene conversion (gBGC). For prokaryotes on the other hand, increase in genomic GC content seems to be driven by the environment and selection. We find that similar phenomena observed for some organisms in each respective domain may be caused by very different mechanisms: while gBGC and recombination rates appear to explain the negative correlation between GC3 (GC content based on the third codon nudeotides) and genome size in some eukaryotes uptake of AT rich DNA sequences is the main reason for a similar negative correlation observed in prokaryotes. We provide further examples that indicate that base composition in prokaryotes and eukaryotes have evolved under very different constraints. 

Place, publisher, year, edition, pages
ELSEVIER , 2019. Vol. 17, p. 362-370
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Evolutionary Biology Genetics
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URN: urn:nbn:se:uu:diva-402958DOI: 10.1016/j.csbj.2019.03.001ISI: 000504205700036PubMedID: 30949307OAI: oai:DiVA.org:uu-402958DiVA, id: diva2:1387614
Available from: 2020-01-22 Created: 2020-01-22 Last updated: 2020-01-22Bibliographically approved

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