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Local adaptation at fine spatial scale through chromosomal inversions and mito-nuclear epistasis: Findings in Drosophila subobscura (Diptera: Drosophilidae)
Univ Belgrade, Fac Biol, Studentski Trg 16, Belgrade 11000, Serbia.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ekselius: Psychiatry. Uppsala Univ, Anim Ecol, Dept Ecol & Genet, Evolutionary Biol Ctr, Norbyvagen 18D, SE-75236 Uppsala, Sweden;Uppsala Univ, Dept Neurosci, Psychiat, SE-75124 Uppsala, Sweden.
Ctr Promot Sci, Belgrade, Serbia.
Univ Belgrade, Fac Biol, Studentski Trg 16, Belgrade 11000, Serbia.
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2019 (English)In: European Journal of Entomology, ISSN 1210-5759, E-ISSN 1802-8829, Vol. 116, p. 492-503Article in journal (Refereed) Published
Abstract [en]

To explore local adaptation in wild populations at a fine spatial scale we characterized the genetic variability of eight closely located populations of Drosophila subobscura and its associations with microhabitat environmental conditions. Three different genetic markers were assessed: chromosomal inversions, a SNP of mitochondrial ND5 gene and nuclear microsatellites. Population genetic analyses of chromosomal variability revealed significant genetic differentiation between these populations. Gene arrangement frequencies on the E chromosome contributed most to these differences. We also investigated role of mitonuclear epistasis in mitochondrial genome differentiation and revealed weak linkage disequilibrium (LD) exclusively between O-3+(4) inversion arrangement and mitochondrial DNA haplotype I in two populations. In addition, the trend in the LD between O-ST chromosomal arrangement and haplotype II was general in the total sample. Microsatellite analysis revealed an absence of stochastic processes, like census reduction, upon population differentiation. Only a small amount of the genetic variation is related to geographic distance, while most (97%) is attributable to other factors and in some degree to microhabitat variables (temperature, humidity). The analysis of these factors revealed they effect inversion arrangement frequencies, especially E1+2+9, E-ST and O-ST. Even though this model organism is known for its high mobility and mostly large effective population size, the results presented here reveal that local adaptations can occur even at a small spatial scale. We propose that locally adapted alleles within chromosomal inversions, as well as joint selective pressures acting on mitochondria! and nuclear genomes, are responsible for the observed adaptation to microhabitat conditions.

Place, publisher, year, edition, pages
2019. Vol. 116, p. 492-503
Keywords [en]
Diptera, Drosophilidae, Drosophila subobscura, genetic differentiation, high dispersion, chromosomal inversion, ND5, microsatellites, local adaptation
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-402625DOI: 10.14411/eje.2019.051ISI: 000505163300005OAI: oai:DiVA.org:uu-402625DiVA, id: diva2:1386466
Available from: 2020-01-17 Created: 2020-01-17 Last updated: 2020-01-17Bibliographically approved

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