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The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.ORCID iD: 0000-0001-6638-1895
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Karolinska Univ Hosp, Div Gynecol & Reprod, Dept Reprod Med, Stockholm, Sweden;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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2019 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 9, article id e028866Article in journal (Refereed) Published
Abstract [en]

Purpose: The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants inferred through the ART procedures and their consequence and (2) to assess the impact of lifestyle and health exposures on treatment outcome.

Participants: Recruitment took place between September 2011 and December 2013, and in vitro fertilisation (IVF) cycles initiated and pregnancies conceived during this time were followed until December 2014. The cohort includes 971 participants (n= 514 women; n= 457 men), and 129 pregnancies were achieved from the first IVF cycle included in the study.

Findings to date: Self-reported demographic, health and lifestyle data were collected from a baseline questionnaire, and to assess changes to lifestyle, a follow-up questionnaire was issued at the time of oocyte retrieval, and at subsequent IVF cycles. Questionnaire data were linked to data extracted from medical records. Biological samples were collected at baseline: blood for extraction of serum, plasma and DNA, morning and evening saliva samples for cortisol measurement and at delivery including samples of maternal blood, placenta and amniotic fluid, and cord blood for epigenetic analysis.

Future plans: Through the unique identification number assigned to each Swedish citizen at birth or immigration, UppStART study participants will be linked to the Swedish population-based national and quality registers to provide data from prenatal, obstetrical, neonatal and infant care, and subsequent updates will provide data on childhood health and educational outcomes. Collaboration and use of UppStART data is encouraged, and more information about access can be found at www.ki.se/meb/uppstart

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2019. Vol. 9, article id e028866
Keywords [en]
assisted reproductive techniques, in vitro fertilisation, infertility, lifestyle, epigenetics
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-402234DOI: 10.1136/bmjopen-2018-028866ISI: 000502537200210PubMedID: 31467051OAI: oai:DiVA.org:uu-402234DiVA, id: diva2:1386136
Funder
EU, FP7, Seventh Framework ProgrammeSwedish Research Council, K2011-69X-21871-01-6Swedish Research Council, SIMSAM 340-2013-5867Available from: 2020-01-16 Created: 2020-01-16 Last updated: 2020-01-16Bibliographically approved

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