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Could Reported Sex Differences in Hypertonic Saline-induced Muscle Pain be a dose Issue?
Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neuroscience, Huddinge, Sweden.ORCID iD: 0000-0002-8346-5289
Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neuroscience, SE 14104 Huddinge, Sweden.
Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neuroscience, SE 14104 Huddinge, Sweden.
Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neuroscience, SE 14104 Huddinge, Sweden.
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2019 (English)In: Dental Oral Biology and Cranofacial Research, ISSN 2613-4950, Vol. 2, no 5, p. 3-8Article in journal (Refereed) Published
Abstract [en]

Higher levels of experimental muscle pain induced by injection of the same volume of noxious substances have been reported by women compared to men. This could hypothetically be related to the difference in muscle volume between men and women. The aim of this study was to investigate if the sex differences reported by intramuscular injection of hypertonic saline would disappear if a larger dose is given to men than women under similar conditions.

Methods: Fifty-six healthy volunteers (25 men and 31 women) received hypertonic saline injection into the masseter muscle, 0.5 mL for men and 0.3 mL for women, to evoke pain. Pain intensity was assessed with 0-100 mm visual analogue scale (VAS) every 15 seconds until pain subsided or maximum 300s. VAS was also used to assess perceived unpleasantness and anxiety. Pain drawings were used to assess maximal pain distribution, and the McGill pain questionnaire to assess pain quality.

Results: There was no sex difference in maximum pain intensity, unpleasantness, anxiety or pain drawing area, but the evoked pain had larger total pain area (p=0.005), and longer duration (p<0.001) in the men than women. The sexes also used some different pain descriptors.

Conclusions: This study shows that the previously reported higher pain levels in women were abolished when a lower dose of hypertonic saline was injected into the masseter muscle of the women than men. This might indicate that the sex differences reported to hypertonic-induced muscle pain may be a dose issue. Further studies are required to validate these results

Place, publisher, year, edition, pages
2019. Vol. 2, no 5, p. 3-8
Keywords [en]
experimental pain, hypertonic saline solution, intramuscular injections, masseter, sex difference, temporomandibular joint disorder
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-167330DOI: 10.31487/j.DOBCR.2019.05.02OAI: oai:DiVA.org:umu-167330DiVA, id: diva2:1386005
Available from: 2020-01-16 Created: 2020-01-16 Last updated: 2020-01-17Bibliographically approved

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Yekkalam, NeginNikolaos, ChristidisErnberg, Malin
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