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A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex-associated Alzheimer's disease
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine. Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Section of Virology.ORCID iD: 0000-0001-9094-319x
Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).
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2019 (English)In: Alzheimer's & dementia, ISSN 1552-5279, Vol. 5, p. 697-704Article in journal (Refereed) Published
Abstract [en]

Introduction: Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis.

Methods: Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age- and sex-matched controls, were analyzed for anti-HSV1 immunoglobulin (Ig) G with enzyme-linked immunosorbent assays (ELISAs). APOE genotype and nine other selected risk genes for AD were extracted from a genome-wide association study analysis by deCODE genetics, Reykjavik, Iceland.

Results: The interaction between APOEε4 heterozygosity (APOEε24 or ε3/ε4) and anti-HSV1 IgG carriage increased the risk of AD (OR 4.55, P = .02). A genetic risk score based on the nine AD risk genes also interacted with anti-HSV1 IgG for the risk of developing AD (OR 2.35, P = .01).

Discussion: The present findings suggest that the APOEε4 allele and other AD genetic risk factors might potentiate the risk of HSV1-associated AD.

Place, publisher, year, edition, pages
2019. Vol. 5, p. 697-704
Keywords [en]
APOEε4, Alzheimer's disease, Apolipoprotein E4, Dementia, HSV, Herpes simplex, Nested case-control study
National Category
Clinical Medicine
Research subject
Medical Virology
Identifiers
URN: urn:nbn:se:umu:diva-167226DOI: 10.1016/j.trci.2019.09.014PubMedID: 31921962OAI: oai:DiVA.org:umu-167226DiVA, id: diva2:1385098
Available from: 2020-01-13 Created: 2020-01-13 Last updated: 2020-01-14Bibliographically approved

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Lopatko Lindman, KarinWeidung, BodilOlsson, JanJosefsson, MariaJohansson, AndersEriksson, StureHallmans, GöranElgh, FredrikLövheim, Hugo
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Geriatric MedicineSection of VirologyCentre for Demographic and Ageing Research (CEDAR)Department of OdontologySection of Sustainable HealthWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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