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Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden;Stockholm Univ, ACES, SE-10691 Stockholm, Sweden.
UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany.
Natl Inst Environm Studies, 16-2 Onogawa, Tsukuba, Ibaraki 3058506, Japan.
Univ Gothenburg, Dept Biol & Environm Sci, Box 461, SE-40530 Gothenburg, Sweden.
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2020 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 134, article id UNSP 105267Article in journal, Letter (Other academic) Published
Abstract [en]

The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, "Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment" was organized in May 2018 together with Joint Research Center in Ispra, EUfunded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages: We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures. Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors. Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps. A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2020. Vol. 134, article id UNSP 105267
Keywords [en]
Chemical mixtures, Environmental chemicals, Combined exposure, Mixture risk assessment, Risk management
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:uu:diva-401998DOI: 10.1016/j.envint.2019.105267ISI: 000501344500079PubMedID: 31704565OAI: oai:DiVA.org:uu-401998DiVA, id: diva2:1384687
Available from: 2020-01-10 Created: 2020-01-10 Last updated: 2020-01-10Bibliographically approved

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