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Digging Back in Evolution: Danger in Drosophila
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
2018 (English)In: Journal of Damage-Associated Molecular Patterns, Vol. 1, no 1, p. 1-8Article, review/survey (Refereed) Published
Abstract [en]

Insects, including the fruit fly, Drosophila melanogaster are used to study a wide array of processes, many of which are known or are expected to be regulated by damage-associated molecular patterns (DAMPs). These include regenerative processes after wounding, replacement of cells by cell competition, induction of immunity and inflammation, responses against tumorous cells and neurodegeneration. Most, if not all of these processes have beneficial outcomes on organismal health but may also lead to pathologies, which often resemble those observed in humans. Drosophila offers unique opportunities to analyze and manipulate genes and pathways related to these immune consequences with high temporal and local resolution. Ultimately, such detailed analyses in the Drosophila model will aid in our understanding of the roles DAMPs play at the bifurcation between physiological and pathological outcomes in other animal species, including humans.

Place, publisher, year, edition, pages
2018. Vol. 1, no 1, p. 1-8
Keywords [en]
Coagulation, Danger signals, DAMPs, Hemocytes, Inflammation, Innate immunity, Insect immunity, Regeneration, Tumors, Wound healing
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-177839OAI: oai:DiVA.org:su-177839DiVA, id: diva2:1383734
Available from: 2020-01-08 Created: 2020-01-08 Last updated: 2020-01-08Bibliographically approved

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