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Smoking and stroke: A mendelian randomization study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.ORCID iD: 0000-0003-0118-0341
Univ Cambridge, Med Res Council, Biostat Unit, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.ORCID iD: 0000-0003-2815-1217
2019 (English)In: Annals of Neurology, ISSN 0364-5134, E-ISSN 1531-8249, Vol. 86, no 3, p. 468-471Article in journal (Refereed) Published
Abstract [en]

We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data for 34,217 ischemic stroke cases and 404,630 noncases, and 1,545 cases of intracerebral hemorrhage and 1,481 noncases. Genetic predisposition to smoking initiation (ever smoking regularly), based on up to 372 single-nucleotide polymorphisms, was statistically significantly positively associated with any ischemic stroke, large artery stroke, and small vessel stroke but not cardioembolic stroke or intracerebral hemorrhage. This study provides genetic support for a causal association of smoking with ischemic stroke, particularly large artery and small vessel stroke. ANN NEUROL 2019;86:468-471

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 86, no 3, p. 468-471
National Category
Neurology
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URN: urn:nbn:se:uu:diva-400092DOI: 10.1002/ana.25534ISI: 000481414700016PubMedID: 31237718OAI: oai:DiVA.org:uu-400092DiVA, id: diva2:1383491
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareSwedish Research CouncilWellcome trust, 204623Available from: 2020-01-08 Created: 2020-01-08 Last updated: 2020-01-08Bibliographically approved

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