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Association between sleep duration and executive function differs between diabetic and non-diabetic middle-aged and older adults.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Schiöth: Functional Pharmacology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.ORCID iD: 0000-0002-8552-4510
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Schiöth: Functional Pharmacology.ORCID iD: 0000-0003-3992-5812
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2020 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 111, article id 104472Article in journal (Refereed) Published
Abstract [en]

Executive function is defined as a set of cognitive skills that are necessary to plan, monitor, and execute a sequence of goal-directed complex actions. Executive function is influenced by a variety of factors, including habitual sleep duration and diabetes. In the present study, we investigated in 18,769 Swedish adults (mean age: 61 y) the association between executive function, diabetes, and self-reported sleep duration. We observed a significant interaction between diabetes and sleep duration for the Trail Making Test (TMT) ratio (P < 0.01). This ratio is a measure of executive function where higher values indicate worse performance. Among diabetic participants (n = 1,523), long (defined as ≥9 h per day) vs. normal sleep duration (defined as 7-8 hours per day) was associated with a higher TMT ratio (P < 0.05). Similar significant results were observed in diabetic individuals without pharmacological treatment for diabetes (n = 1,062). Among non-diabetic participants (n = 17,246), no association between long sleep duration and the TMT ratio was observed (P > 0.05). Instead, short (defined as <7 h per day) vs. normal sleep duration was linked to a higher TMT ratio (P < 0.05). These findings suggest that the association between sleep duration and executive function differs between diabetic and non-diabetic middle-aged and older adults. Based on the cross-sectional design of the study, no firm conclusions can be drawn on the causality of the relations.

Place, publisher, year, edition, pages
2020. Vol. 111, article id 104472
Keywords [en]
Cohort study, Diabetes, Executive function, Sleep duration
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-401482DOI: 10.1016/j.psyneuen.2019.104472ISI: 000503085600005PubMedID: 31610410OAI: oai:DiVA.org:uu-401482DiVA, id: diva2:1383440
Funder
Novo Nordisk, NNF190C0056777The Swedish Brain Foundation, F02019-0028Swedish Research Council, 2015-03100Åke Wiberg Foundation, M18-0169Fredrik och Ingrid Thurings Stiftelse, 2018-00365Swedish Society for Medical Research (SSMF), P18-0084Available from: 2020-01-08 Created: 2020-01-08 Last updated: 2020-01-22Bibliographically approved

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