Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa
Univ Kiel, Dept Evolutionary Ecol & Genet, Kiel, Germany.ORCID iD: 0000-0003-0433-9311
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Univ Kiel, Dept Evolutionary Ecol & Genet, Kiel, Germany;Max Planck Inst Evolutionary Biol, Plon, Germany.ORCID iD: 0000-0001-9480-5261
UKSH, Inst Clin Mol Biol, Kiel, Germany.
Univ Kiel, Dept Evolutionary Ecol & Genet, Kiel, Germany;Max Planck Inst Evolutionary Biol, Plon, Germany.
2019 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e51481Article in journal (Refereed) Published
Abstract [en]

Evolution is at the core of the impending antibiotic crisis. Sustainable therapy must thus account for the adaptive potential of pathogens. One option is to exploit evolutionary trade-offs, like collateral sensitivity, where evolved resistance to one antibiotic causes hypersensitivity to another one. To date, the evolutionary stability and thus clinical utility of this trade-off is unclear. We performed a critical experimental test on this key requirement, using evolution experiments with Pseudomonas aeruginosa, and identified three main outcomes: (i) bacteria commonly failed to counter hypersensitivity and went extinct; (ii) hypersensitivity sometimes converted into multidrug resistance; and (iii) resistance gains frequently caused re-sensitization to the previous drug, thereby maintaining the trade-off. Drug order affected the evolutionary outcome, most likely due to variation in the effect size of collateral sensitivity, epistasis among adaptive mutations, and fitness costs. Our finding of robust genetic trade-offs and drug-order effects can guide design of evolution-informed antibiotic therapy.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, article id e51481
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-400100DOI: 10.7554/eLife.51481ISI: 000499725400001PubMedID: 31658946OAI: oai:DiVA.org:uu-400100DiVA, id: diva2:1383021
Funder
German Research Foundation (DFG), SCHU 1415/12-1German Research Foundation (DFG), EXC 22167-39088401Max Planck SocietyAvailable from: 2020-01-07 Created: 2020-01-07 Last updated: 2020-01-07Bibliographically approved

Open Access in DiVA

fulltext(1472 kB)8 downloads
File information
File name FULLTEXT01.pdfFile size 1472 kBChecksum SHA-512
ba6174f61f2bae9538e1c81f0d11317a73730d35b5c431c081b2110f56299bda475fcb9f23bcbf5187028cda6486fb7544c5c3840889b9bf482e8abbb368a84d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Barbosa, CamiloRömhild, Roderich
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
eLIFE
Evolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 8 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf