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A hybrid of cells and pancreatic islets toward a new bioartificial pancreas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Univ Tokyo, Dept Bioengn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan.ORCID iD: 0000-0002-0709-1000
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Linnaeus Univ, Linnaeus Ctr Biomat Chem, SE-39182 Kalmar, Sweden.ORCID iD: 0000-0001-7888-1571
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
2016 (English)In: REGENERATIVE THERAPY, ISSN 2352-3204, Vol. 3, p. 68-74Article, review/survey (Refereed) Published
Abstract [en]

Cell surface engineering using single-stranded DNA-poly(ethylene glycol)-conjugated phospholipid (ssDNA-PEG-lipid) is useful for inducing cell-cell attachment two and three dimensionally. In this review, we summarize our recent techniques for cell surface engineering and their applications to islet transplantation. Because any DNA sequence can be immobilized onto the cell surface by hydrophobic interactions between ssDNA-PEG-lipid and the cellular membrane without impairing cell function, a cell-cell hybrid can be formed through the DNA hybridization. With this technique, it would be possible to create three-dimensional hybrid structures of pancreatic islets coated with various accessory cells, such as patients' own cells, mesenchymal and adipose-derived stem cells, endothelial progenitor cells, neural crest stem cells or regulatory T cells, which might significantly improve the outcome of islet transplantation in diabetic patients.

Place, publisher, year, edition, pages
2016. Vol. 3, p. 68-74
Keywords [en]
Cell surface modification, PEG-conjugated phospholipid (PEG-lipid), Pancreatic islet, Instant blood-mediated inflammatory reaction (IBMIR), Diabetes
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-400850DOI: 10.1016/j.reth.2016.03.004ISI: 000418834300011PubMedID: 31245475OAI: oai:DiVA.org:uu-400850DiVA, id: diva2:1382971
Available from: 2020-01-07 Created: 2020-01-07 Last updated: 2020-01-07Bibliographically approved

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