Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Optimization of Islet Microencapsulation with Thin Polymer Membranes for Long-Term Stability
Shibaura Inst Technol, Coll Syst Engn & Sci, Dept Biosci & Engn, Saitama 3378570, Japan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Univ Tokyo, Sch Engn, Dept Bioengn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan.
Shibaura Inst Technol, Coll Syst Engn & Sci, Dept Biosci & Engn, Saitama 3378570, Japan.
Show others and affiliations
2019 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 10, no 11, article id 755Article in journal (Refereed) Published
Abstract [en]

Microencapsulation of islets can protect against immune reactions from the host immune system after transplantation. However, sufficient numbers of islets cannot be transplanted due to the increase of the size and total volume. Therefore, thin and stable polymer membranes are required for the microencapsulation. Here, we undertook the cell microencapsulation using poly(ethylene glycol)-conjugated phospholipid (PEG-lipid) and layer-by-layer membrane of multiple-arm PEG. In order to examine the membrane stability, we used different molecular weights of 4-arm PEG (10k, 20k and 40k)-Mal to examine the influence on the polymer membrane stability. We found that the polymer membrane made of 4-arm PEG(40k)-Mal showed the highest stability on the cell surface. Also, the polymer membrane did not disturb the insulin secretion from beta cells.

Place, publisher, year, edition, pages
2019. Vol. 10, no 11, article id 755
Keywords [en]
microencapsulation, bioartificial pancreas, islet transplantation, polyethylene glycol-lipid (PEG-lipid), cell surface modification
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-400755DOI: 10.3390/mi10110755ISI: 000502255300041PubMedID: 31698737OAI: oai:DiVA.org:uu-400755DiVA, id: diva2:1382559
Funder
Swedish Research Council, 2018-04199Swedish Research Council, 2016-2075-5.1Swedish Research Council, 2016-04519Available from: 2020-01-03 Created: 2020-01-03 Last updated: 2020-01-03Bibliographically approved

Open Access in DiVA

fulltext(3668 kB)8 downloads
File information
File name FULLTEXT01.pdfFile size 3668 kBChecksum SHA-512
be2c754edc0dc9919147918019a9d03407c2bd3a909fbfbe3a8d817f4bd78b37fd3dce588075347d70b251ba440954f34b712a0d71e6aac9010bdce32828da3c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nilsson Ekdahl, KristinaNilsson, BoTeramura, Yuji
By organisation
Department of Immunology, Genetics and PathologyClinical Immunology
In the same journal
Micromachines
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
Total: 8 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf