Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Department of Surgery, Gävle Hospital, Gävle, Sweden.ORCID iD: 0000-0003-1621-7872
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0002-4394-2634
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0002-5440-791x
2020 (English)In: Annals of Surgical Oncology, ISSN 1068-9265, E-ISSN 1534-4681Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: The purpose of this study was to investigate whether pT3-4 and pN-subclassifications, lymph-node ratio (LNR), tumour deposits, pre- and postoperative carcinoembryonic antigen (CEA), and C-reactive protein (CRP)-all parameters commonly collected in clinical management-add information about recurrence risk against a background of routine clinicopathological parameters as defined by the NCCN.

METHODS: The prospective cohort consisted of all 416 patients diagnosed with colon cancer stage I-III in Uppsala County between 2010 and 2015. Cox proportional hazard models were used to calculate hazard ratios for time to recurrence and overall survival. The results were compared with the entire Swedish population concerning parameters recorded in the national quality registry, SCRCR, during the same time period.

RESULTS: The Uppsala cohort was representative of the entire Swedish cohort. In unadjusted analyses, pT3-subclassification, pN-subclassification, LNR, tumour deposits, elevated postoperative CEA, and preoperative CRP correlated with recurrence. After adjusting for T-, N-stage, and NCCN risk factors, pN-subclassification, sidedness, and elevated postoperative CEA levels correlated with recurrence. Survival correlated with parameters associated with recurrence, LNR, and elevated postoperative CRP.

CONCLUSIONS: Additional information on recurrence risk is available from several routinely recorded parameters, but most of the risk is predicted by the commonly used clinicopathological parameters.

Place, publisher, year, edition, pages
2020.
National Category
Clinical Medicine
Research subject
Oncology
Identifiers
URN: urn:nbn:se:uu:diva-400792DOI: 10.1245/s10434-019-08148-3PubMedID: 31893351OAI: oai:DiVA.org:uu-400792DiVA, id: diva2:1382438
Funder
Swedish Cancer Society, CAN 2016/447Available from: 2020-01-03 Created: 2020-01-03 Last updated: 2020-01-17Bibliographically approved

Open Access in DiVA

fulltext(379 kB)17 downloads
File information
File name FULLTEXT01.pdfFile size 379 kBChecksum SHA-512
07f0f08e0f9e2e77e71720021d1545caf607be14516be71c5de4a2ea33c5667f59c866f11e178cb3c2f5ea08b6c18893fc24b2e887ce91ab6e6a66134b7966ed
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Osterman, ErikMezheyeuski, ArturSjöblom, TobiasGlimelius, Bengt
By organisation
Experimental and Clinical OncologyScience for Life Laboratory, SciLifeLab
In the same journal
Annals of Surgical Oncology
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 17 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 72 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf