Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Programmed DNA elimination of germline development genes in songbirds
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Uppsala University, Science for Life Laboratory, SciLifeLab. Univ Amsterdam, Amsterdam UMC, Dept Med Microbiol, Lab Expt Virol, NL-1105 AZ Amsterdam, Netherlands.ORCID iD: 0000-0001-9865-4608
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. Univ Granada, Dept Genet, E-18071 Granada, Spain.ORCID iD: 0000-0002-5391-301x
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Uppsala University, Science for Life Laboratory, SciLifeLab. Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA;Univ Moncton, Dept Biol, Moncton, NB E1A 3E9, Canada.
Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England.
Show others and affiliations
2019 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 5468Article in journal (Refereed) Published
Abstract [en]

In some eukaryotes, germline and somatic genomes differ dramatically in their composition. Here we characterise a major germline-soma dissimilarity caused by a germline-restricted chromosome (GRC) in songbirds. We show that the zebra finch GRC contains >115 genes paralogous to single-copy genes on 18 autosomes and the Z chromosome, and is enriched in genes involved in female gonad development. Many genes are likely functional, evidenced by expression in testes and ovaries at the RNA and protein level. Using comparative genomics, we show that genes have been added to the GRC over millions of years of evolution, with embryonic development genes bicc1 and trim71 dating to the ancestor of songbirds and dozens of other genes added very recently. The somatic elimination of this evolutionarily dynamic chromosome in songbirds implies a unique mechanism to minimise genetic conflict between germline and soma, relevant to antagonistic pleiotropy, an evolutionary process underlying ageing and sexual traits.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 10, article id 5468
National Category
Evolutionary Biology Genetics
Identifiers
URN: urn:nbn:se:uu:diva-400663DOI: 10.1038/s41467-019-13427-4ISI: 000500473200001PubMedID: 31784533OAI: oai:DiVA.org:uu-400663DiVA, id: diva2:1382435
Funder
Swedish Research Council Formas, 2017-01597Swedish Research Council, 2016-05139Knut and Alice Wallenberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience, 2015-R14Available from: 2020-01-03 Created: 2020-01-03 Last updated: 2020-01-03Bibliographically approved

Open Access in DiVA

fulltext(2064 kB)5 downloads
File information
File name FULLTEXT01.pdfFile size 2064 kBChecksum SHA-512
d6bcd375f837940b5f7b5428dc7f78df36c1c9902345cb0f06eb36d72c5352f5b3a0ecc0d03cb48d38ee204e01460e696a2eea846eb5556c3827b51e2f429a44
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kinsella, Cormac M.Ruiz-Ruano, Francisco J.Gossmann, Toni I.Kappei, DennisCamacho, Juan Pedro M.Suh, Alexander
By organisation
Evolutionary BiologyScience for Life Laboratory, SciLifeLabSystematic Biology
In the same journal
Nature Communications
Evolutionary BiologyGenetics

Search outside of DiVA

GoogleGoogle Scholar
Total: 5 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 6 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf