Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Brachial pulse pressure in acute heart failure. Results of the Heart Failure Registry
Osped Sacro Cuore Don Calabria, Italy.
Univ Verona, Italy.
European Soc Cardiol, France.
Complexo Hosp Univ A Coruna, Spain; Inst Invest Biomed, Spain; Univ A Coruna, Spain; Ctr Invest Red Enfermedades Cardiovasc, Spain.
Show others and affiliations
2019 (English)In: ESC Heart Failure, E-ISSN 2055-5822, Vol. 6, no 6, p. 1167-1177Article in journal (Refereed) Published
Abstract [en]

Aims To investigate the still uncertain independent prognostic impact of pulse pressure (PP) in acute heart failure (HF), in particular across the left ventricular ejection fraction (EF) phenotypes, and the potential contribution of PP in outlining the individual phenotypes. Methods and results We prospectively evaluated 1-year death and rehospitalization in 4314 patients admitted for acute HF grouped by EF and stratified by their PP level on admission. In HF with reduced (amp;lt; 40%) EF (HFrEF), the highest quartiles of PP had the lowest unadjusted [hazard ratio (HR) 0.77, 95% confidence interval (CI) 0.61-0.98] and adjusted (HR 0.64 0.50-0.82) risk of 1 year all cause death compared to the lowest quartile. Its prognostic impact was partially mediated by systolic blood pressure (SBP). In HF with preserved (amp;gt;= 50%) EF (HFpEF), the intermediate quartile of PP showed the lowest 1 year all cause mortality in unadjusted (HR 0.598, CI 0.416-0.858) and adjusted (HR 0.55, 95% CI 0.388-0.801) models with no relationship with SBP. In a receiver operating characteristic analysis, a combination of PP amp;gt; 60 mmHg and SBP amp;gt; 140 mmHg was associated to a preserved EF with a high performance value. No prognostic significance of PP was found in the HF with mid-range EF subgroup. Conclusions In acute HFrEF, there is an almost linear inverse relation between mortality and PP, partly mediated by SBP. In HFpEF, a J-shaped relationship between mortality and PP was present with a better prognosis at the nadir. A combination of PP amp;gt; 60 mmHg with SBP amp;gt; 140 mmHg may be clinically helpful as marker of a preserved left ventricular EF.

Place, publisher, year, edition, pages
WILEY PERIODICALS, INC , 2019. Vol. 6, no 6, p. 1167-1177
Keywords [en]
Pulse pressure; Heart Failure; Acute Heart Failure; Prognosis
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-162864DOI: 10.1002/ehf2.12537ISI: 000501354800001PubMedID: 31814303OAI: oai:DiVA.org:liu-162864DiVA, id: diva2:1382275
Note

Funding Agencies|Abbott Vascular International; Amgen Cardiovascular; AstraZenecaAstraZeneca; Bayer AGBayer AG; Boehringer IngelheimBoehringer Ingelheim; Boston ScientificBoston Scientific; Bristol Myers SquibbBristol-Myers Squibb; Pfizer Alliance; Alliance Daiichi Sankyo Europe GmbH; Eli Lilly and CompanyEli Lilly; Daiichi Sankyo EuropeDaiichi Sankyo Company Limited; Edwards; Gedeon Richter plc; Menarini International Op.; MSD-Merck Co.; Novartis Pharma AG; ResMed; Sanofi; ServierServier; Vifor

Available from: 2020-01-02 Created: 2020-01-02 Last updated: 2020-04-08

Open Access in DiVA

fulltext(303 kB)19 downloads
File information
File name FULLTEXT01.pdfFile size 303 kBChecksum SHA-512
c2546962cc90dd7c4304041d7292b879dabb74d8a692bbc59805373771aba32352498b55c613fbc14160a570ff879779d9720d944f8ef69a010dc13c9d3e2c35
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Dahlström, Ulf
By organisation
Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Linköping
In the same journal
ESC Heart Failure
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
Total: 19 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 22 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf