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Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Neurosciences. Department of Neurosurgery, University Hospital of Northern Sweden, 901 85 Umeå, Sweden.ORCID iD: 0000-0002-8258-0699
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0002-6169-5155
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
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2019 (English)In: Journal of Neuro-Oncology, ISSN 0167-594X, E-ISSN 1573-7373, Vol. 145, no 2, p. 287-294Article in journal (Refereed) Published
Abstract [en]

Background: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Preclinical studies suggest that this enzyme may contribute to an environment favorable for growth of malignant glioma. The MAO-A gene is located on the X-chromosome and has at least one functional genetic polymorphism. The aim of the present study was to explore possible effects of MAO-A genotype on development of glioblastoma in males.

Methods: Genotypes for 437 glioma cases and 876 population-based controls from the Swedish Glioma International Case–Control study (GICC) were compared. We analyzed the germline DNA using the Illumina Oncoarray. We selected seven single nucleotide polymorphisms (SNPs) located in the MAO-A gene, and imputed genotypes based on data from the 1000 genomes project. We used 1579 male glioblastoma cases and 1875 controls comprising the whole GICC cohort for subsequent validation of findings.

Results: The rs144551722 SNP was a significant predictor of development of glioblastoma in males (p-value = 0.0056) but not in females even after correction for multiple testing. We conducted haplotype analysis to confirm an association between MAO-A gene and risk of glioblastoma (p-value = 0.016). We found similar results in the validation sample.

Conclusions: These results suggest the possibility of a role for the MAO-A enzyme and the MAO-A gene in the development of glioblastoma in males.

Place, publisher, year, edition, pages
Springer, 2019. Vol. 145, no 2, p. 287-294
Keywords [en]
MAOA genetics glioblastoma males
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-166478DOI: 10.1007/s11060-019-03294-wISI: 000496571900010PubMedID: 31556016OAI: oai:DiVA.org:umu-166478DiVA, id: diva2:1382158
Funder
NIH (National Institute of Health), R01CA139020NIH (National Institute of Health), R01 CA139020Available from: 2020-01-02 Created: 2020-01-02 Last updated: 2020-01-02Bibliographically approved

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