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Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics
Univ Oulu, Oulu Univ Hosp, Med Res Ctr, Dept Obstet & Gynecol,PEDEGO Res Unit, Oulu, Finland.
Univ Helsinki, Haartman Inst, Transplantat Lab, Helsinki, Finland;Helsinki Univ Hosp, HUSLAB, Helsinki, Finland.
Univ Helsinki, Haartman Inst, Transplantat Lab, Helsinki, Finland;Helsinki Univ Hosp, HUSLAB, Helsinki, Finland.
Univ Oulu, Oulu Univ Hosp, Med Res Ctr, Dept Obstet & Gynecol,PEDEGO Res Unit, Oulu, Finland.
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2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 17578Article in journal (Refereed) Published
Abstract [en]

Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder of fertile-aged women. Several adverse pregnancy outcomes and abnormalities of the placenta have been associated with PCOS. By using quantitative label-free proteomics we investigated whether changes in the plasma proteome of pregnant women with PCOS could elucidate the mechanisms behind the pathologies observed in PCOS pregnancies. A total of 169 proteins with >= 2 unique peptides were detected to be differentially expressed between women with PCOS (n = 7) and matched controls (n = 20) at term of pregnancy, out of which 35 were significant (p-value < 0.05). A pathway analysis revealed that networks related to humoral immune responses, inflammatory responses, cardiovascular disease and cellular growth and proliferation were affected by PCOS. Classification of cases and controls was carried out using principal component analysis, orthogonal projections on latent structure-discriminant analysis (OPLS-DA), hierarchical clustering, self-organising maps and ROC-curve analysis. The most significantly enriched proteins in PCOS were properdin and insulin-like growth factor II. In the dataset, properdin had the best predictive accuracy for PCOS (AUC=1). Additionally, properdin abundances correlated with AMH levels in pregnant women.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 17578
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Obstetrics, Gynecology and Reproductive Medicine
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URN: urn:nbn:se:uu:diva-400110DOI: 10.1038/s41598-019-54067-4ISI: 000498607500002PubMedID: 31772271OAI: oai:DiVA.org:uu-400110DiVA, id: diva2:1380248
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Academy of FinlandAvailable from: 2019-12-18 Created: 2019-12-18 Last updated: 2019-12-18Bibliographically approved

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