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An ultrafast system for signaling mechanical pain in human skin
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
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2019 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 5, no 7, article id eaaw1297Article in journal (Refereed) Published
Abstract [en]

The canonical view is that touch is signaled by fast-conducting, thickly myelinated afferents, whereas pain is signaled by slow-conducting, thinly myelinated (“fast” pain) or unmyelinated (“slow” pain) afferents. While other mammals have thickly myelinated afferents signaling pain (ultrafast nociceptors), these have not been demonstrated in humans. Here, we performed single-unit axonal recordings (microneurography) from cutaneous mechanoreceptive afferents in healthy participants. We identified A-fiber high-threshold mechanoreceptors (A-HTMRs) that were insensitive to gentle touch, encoded noxious skin indentations, and displayed conduction velocities similar to A-fiber low-threshold mechanoreceptors. Intraneural electrical stimulation of single ultrafast A-HTMRs evoked painful percepts. Testing in patients with selective deafferentation revealed impaired pain judgments to graded mechanical stimuli only when thickly myelinated fibers were absent. This function was preserved in patients with a loss-of-function mutation in mechanotransduction channel PIEZO2. These findings demonstrate that human mechanical pain does not require PIEZO2 and can be signaled by fast-conducting, thickly myelinated afferents.

Place, publisher, year, edition, pages
American Association for the Advancement of Science , 2019. Vol. 5, no 7, article id eaaw1297
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Neurosciences
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URN: urn:nbn:se:umu:diva-166419DOI: 10.1126/sciadv.aaw1297ISI: 000478770400048PubMedID: 31281886Scopus ID: 2-s2.0-85068598091OAI: oai:DiVA.org:umu-166419DiVA, id: diva2:1379230
Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2019-12-16Bibliographically approved

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