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Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study
Lund University, Malmö, Sweden; Skåne University Hospital, Lund and Malmö, Sweden.
Lund University, Malmö, Sweden; Skåne University Hospital, Lund and Malmö, Sweden.ORCID iD: 0000-0003-0194-8402
Lund University, Malmö, Sweden; Skåne University Hospital, Lund and Malmö, Sweden.
Lund University, Malmö, Sweden; Skåne University Hospital, Lund and Malmö, Sweden.
2014 (English)In: BMC Neurology, ISSN 1471-2377, E-ISSN 1471-2377, Vol. 14, article id 64Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The Insulin-like Growth Factor (IGF)-related system is implicated in neuroregeneration and cell repair, as well as regulating lifespan. IGF-II, one component of this system, has also been found to affect memory functions in a rat model. In this study we explored changes in the IGF-related system in patients with Alzheimer's disease (AD), including changes in IGF-II levels.

METHODS: We measured blood plasma and cerebrospinal fluid (CSF) levels of IGF-I, IGF-II, IGFBP-2 and IGFBP-3 in 72 healthy controls and 92 patients with AD.

RESULTS: We found significantly lower blood plasma levels of IGF-II and IGFBP-3 in patients with AD, compared with controls. The levels of IGF-II and IGFBP-2 were significantly elevated in the CSF from patients with AD. We also found correlations between established CSF biomarkers for AD (tau and P-tau) and components of the IGF system.

CONCLUSIONS: CSF and blood plasma levels of IGF-II and some of its binding proteins are changed in patients with AD. Further investigation into this area may unravel important clues to the nature of this disease.

Place, publisher, year, edition, pages
BioMed Central, 2014. Vol. 14, article id 64
National Category
Geriatrics Neurology
Identifiers
URN: urn:nbn:se:liu:diva-162685DOI: 10.1186/1471-2377-14-64ISI: 000333689900002PubMedID: 24685003Scopus ID: 2-s2.0-84897370805OAI: oai:DiVA.org:liu-162685DiVA, id: diva2:1379214
Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2020-01-22Bibliographically approved

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