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Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation
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2017 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 21, no 7, p. 2017-2029Article in journal (Refereed) Published
Abstract [en]

The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized nature of gametogenesis allowed us to investigate phosphorylation signaling during its first minute in Plasmodium berghei via a high-resolution time course of the phosphoproteome. This revealed an unexpectedly broad response, with proteins related to distinct cell cycle events undergoing simultaneous phosphoregulation. We implicate several protein kinases in the process, and we validate our analyses on the plant-like calcium-dependent protein kinase 4 (CDPK4) and a homolog of serine/arginine-rich protein kinases (SRPK1). Mutants in these kinases displayed distinct phosphoproteomic disruptions, consistent with differences in their phenotypes. The results reveal the central role of protein phosphorylation in the atypical cell cycle regulation of a divergent eukaryote.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 21, no 7, p. 2017-2029
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Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-165834DOI: 10.1016/j.celrep.2017.10.071ISI: 000415073200025PubMedID: 29141230OAI: oai:DiVA.org:umu-165834DiVA, id: diva2:1379075
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Wellcome trust, WT098051Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2019-12-18Bibliographically approved

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