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Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes
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2017 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 170, no 2, p. 260-272.e1-e4Article in journal (Refereed) Published
Abstract [en]

The genomes of malaria parasites contain many genes of unknown function. To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei knockout mutants, representing >50% of the genome, and created a phenotype database. At a single stage of its complex life cycle, P. berghei requires two-thirds of genes for optimal growth, the highest proportion reported from any organism and a probable consequence of functional optimization necessitated by genomic reductions during the evolution of parasitism. In contrast, extreme functional redundancy has evolved among expanded gene families operating at the parasite-host interface. The level of genetic redundancy in a single-celled organism may thus reflect the degree of environmental variation it experiences. In the case of Plasmodium parasites, this helps rationalize both the relative successes of drugs and the greater difficulty of making an effective vaccine.

Place, publisher, year, edition, pages
Cell Press , 2017. Vol. 170, no 2, p. 260-272.e1-e4
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Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-165835DOI: 10.1016/j.cell.2017.06.030ISI: 000405493900007PubMedID: 28708996OAI: oai:DiVA.org:umu-165835DiVA, id: diva2:1379067
Funder
Wellcome trust, 098051
Note

Supplemental Figures

Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2019-12-18Bibliographically approved

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