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Defect root cementum of primary teeth in children with x-linked hypophosphatemia
Jönköping University, School of Health and Welfare, HHJ. CHILD. Odontologiska Instutitionen i Jönköping.ORCID iD: 0000-0003-3123-753X
2019 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Defect root cementum of primary teeth in children with x-linked hypophosphatemia

Norderyd J. National Oral disability Centre for Rare Disorders, The Institute for Postgraduate Dental Education, Jönköping, Sweden and CHILD research group, Swedish Institute for Disability Research, School of Health and Welfare, Jönköping University, Jönköping, Sweden.

Background X-linked hypophosphatemia (XLH) is a rare disorder where low phosphate levels affect the mineralisation of bone and teeth.  The main and well-known dental complications are pulpal infections and abscesses attributed to large pulpal chambers and defective dentine. Increased risk for periodontal disease has also been described and recently, defect root cementum was suggested as a likely aetiology behind periodontal attachment loss in adults with XLH (Biosse Duplan et al 2017). However, no reports describing root cementum defects in primary teeth in children with XLH has to this date been published. The National Oral Disability Centre for Rare Disorders in Jönköping, Sweden, receives many consultations about patients where dental complications are part of a rare syndrome and XLH is one of those.  

Aim The aim of this project was to search the National Oral Disability Centre’s consultations about XLH and retrospectively check for root cementum defects described in histological analyses of extracted primary teeth. Results Ten children with confirmed XLH were identified among the consultations to the centre from different parts of Sweden during 2004 to 2018. Five of these children had had a primary tooth sent for biopsy diagnosis. In one analysis, the oldest, the root cementum is not mentioned. The other four biopsy diagnoses describe teeth with globular dentin, typical for XLH, and they also reveal aplastic and/or hypoplastic root cementum.

Conclusions - XLH can be added to the list of diagnoses where hypoplastic root cementum in primary teeth may be part of the syndrome.   - In addition to the well-known risk for dental abscesses due to defect dentine, children with XLH may also have an increased risk for early periodontal problems because of dysplastic root cementum.   - Preventive measures should focus both on keeping the enamel intact and on periodontal health. - Even when the XLH diagnosis is already medically and/or genetically verified, there is a value for individuals with XLH to have an extracted or lost primary or permanent tooth sent for biopsy diagnoses of dentin as well as root cementum. 

Place, publisher, year, edition, pages
2019.
Keywords [en]
X-linked hypophosphatemia, root cementum
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hj:diva-47092OAI: oai:DiVA.org:hj-47092DiVA, id: diva2:1378980
Conference
27th Congress of the International Association for Paediatric Dentistry 3-7 July 2019, Cancun, Mexico
Funder
Futurum - Academy for Health and Care, Jönköping County Council, Sweden, 909031 resebidragAvailable from: 2019-12-16 Created: 2019-12-16 Last updated: 2019-12-16Bibliographically approved

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