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Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry. Turku PET Centre, Åbo Akademi, 20520 Turku, Finland.ORCID iD: 0000-0002-2515-8790
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.ORCID iD: 0000-0001-8843-7941
2019 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, no 23, article id E5827Article in journal (Refereed) Published
Abstract [en]

Type 1 diabetes (T1D) is characterized by the loss of insulin-producing cells and hence insulin secretion and metabolic control. In addition to insulin, there are a number of hormones and cytokines that influence metabolism, and many of these can be secreted from brown adipose tissue (BAT). However, the presence and activity of BAT in T1D have not been studied, despite the fact that preclinical studies have shown that transplantation of BAT in mouse models of T1D can restore metabolic control. The metabolic activity of BAT, white adipose tissue (WAT), and skeletal muscle was investigated in patients with T1D (n = 11) by 2-deoxy-2-(18F)fluoro-D-glucose PET/CT after cold stimulation. Functional BAT was detected in 4 out of 11 individuals with T1D with a prevalence of 36%. The glucose utilization rate in the supraclavicular BAT regions ranged from 0.75-38.7 µmol × min-1 × 100 g-1. The glucose utilization per gram tissue was higher in BAT when compared with both WAT (p = 0.049) and skeletal muscle (p = 0.039). However, no correlation between BAT activity and metabolic control or insulin requirements was found. In conclusion, for the first time, cold-induced BAT was detected in patients with T1D with a wide range in metabolic activity. Contrary to findings in animal models, the metabolic activity of BAT had negligible impact on insulin requirements or metabolic control in T1D under normal physiological conditions.

Place, publisher, year, edition, pages
2019. Vol. 20, no 23, article id E5827
Keywords [en]
brown adipose tissue, metabolic control, positron emission tomography, type 1 diabetes
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-399124DOI: 10.3390/ijms20235827ISI: 000504428300009PubMedID: 31757005OAI: oai:DiVA.org:uu-399124DiVA, id: diva2:1377804
Funder
Magnus Bergvall FoundationFredrik och Ingrid Thurings StiftelseScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceEXODIAB - Excellence of Diabetes Research in SwedenAvailable from: 2019-12-12 Created: 2019-12-12 Last updated: 2020-01-22Bibliographically approved

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Eriksson, OlofSelvaraju, RamkumarBerglund, MarieEspes, Daniel
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Science for Life Laboratory, SciLifeLabDepartment of Medicinal ChemistryDepartment of Public Health and Caring SciencesDepartment of Medical Cell BiologyTransplantation and regenerative medicine
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