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Neuropeptide Y in itch regulation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Lagerström: Sensory circuits. Uppsala Univ, Dept Neurosci, Husargatan 3,Box 593, S-75124 Uppsala, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Lagerström: Sensory circuits.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Lagerström: Sensory circuits.
2019 (English)In: Neuropeptides, ISSN 0143-4179, E-ISSN 1532-2785, Vol. 78, article id 101976Article, review/survey (Refereed) Published
Abstract [en]

Itch is a somatosensory sensation that informs the organism about the presence of potentially harmful substances or parasites, and initiates scratching to remove the threat. Itch-inducing (pruritogenic) substances activate primary afferent neurons in the skin through interactions with specific receptors that converts the stimulus into an electrical signal. These signals are conveyed to the dorsal horn of the spinal cord through the release of neurotransmitters such as natriuretic polypeptide b and somatostatin, leading to an integrated response within a complex spinal inteneuronal network. A large sub-population of somatostatin-expressing spinal interneurons also carry the Neuropeptide Y (NPY) Y1 receptor, indicating that NPY and somatostatin partly regulate the same neuronal pathway. This review focuses on recent findings regarding the role of the NPY/Y1 and somatostatin/SST2A receptor in itch, and also presents data integrating the two neurotransmitter systems.

Place, publisher, year, edition, pages
2019. Vol. 78, article id 101976
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-398793DOI: 10.1016/j.npep.2019.101976ISI: 000497598400001PubMedID: 31668651OAI: oai:DiVA.org:uu-398793DiVA, id: diva2:1377300
Funder
Swedish Research CouncilThe Swedish Brain FoundationStiftelsen Olle Engkvist ByggmästareRagnar Söderbergs stiftelseAvailable from: 2019-12-11 Created: 2019-12-11 Last updated: 2019-12-11Bibliographically approved

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