Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics
Univ Penn, Dept Surg, Div Transplantat, Philadelphia, PA 19104 USA.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden.
Show others and affiliations
2019 (English)In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 10, article id 2539Article, review/survey (Refereed) Published
Abstract [en]

Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders.

Place, publisher, year, edition, pages
2019. Vol. 10, article id 2539
Keywords [en]
clinical trial, laboratory investigation, immunoassays, functional assays, CV%
National Category
Immunology in the medical area Immunology
Identifiers
URN: urn:nbn:se:uu:diva-398795DOI: 10.3389/fimmu.2019.02539ISI: 000498927000001PubMedID: 31787968OAI: oai:DiVA.org:uu-398795DiVA, id: diva2:1377287
Funder
Swedish Research Council, 2015-06429Swedish Research Council, 2016-2075-5.1Swedish Research Council, 2016-04519
Note

Maedeh Mohebnasab and Oskar Eriksson are joint first authors.

Available from: 2019-12-11 Created: 2019-12-11 Last updated: 2020-01-08Bibliographically approved

Open Access in DiVA

fulltext(719 kB)15 downloads
File information
File name FULLTEXT01.pdfFile size 719 kBChecksum SHA-512
c22e46e8535ab1cb1bb6dae17eccdf85224fd09ff1510ef089ddf73b646e6efb599af4bae9a37a8f821206e67cc6e7738b692cab25a1184493f2cbeddcd25283
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Eriksson, OskarPersson, BarbroNilsson Ekdahl, KristinaNilsson, Bo
By organisation
Clinical Immunology
In the same journal
Frontiers in Immunology
Immunology in the medical areaImmunology

Search outside of DiVA

GoogleGoogle Scholar
Total: 15 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 43 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf