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Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala Univ, Sci Life Lab, Dept Med Chem, Uppsala, Sweden.ORCID iD: 0000-0002-2515-8790
2020 (English)In: Theranostics, ISSN 1838-7640, E-ISSN 1838-7640, Vol. 10, no 1, p. 437-461Article, review/survey (Refereed) Published
Abstract [en]

In the light of theranostics/radiotheranostics and prospective of personalized medicine in diabetes and oncology, this review presents prior and current advances in the development of radiolabeled imaging and radiotherapeutic exendin-based agents targeting glucagon-like peptide-1 receptor. The review covers chemistry, preclinical, and clinical evaluation. Such critical aspects as structure-activity-relationship, stability, physiological potency, kidney uptake, and dosimetry are discussed.

Place, publisher, year, edition, pages
2020. Vol. 10, no 1, p. 437-461
Keywords [en]
Exendin-4, insulinoma, GLP-1, diabetes, PET, SPECT
National Category
Cancer and Oncology Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-398791DOI: 10.7150/thno.38366ISI: 000497314800030OAI: oai:DiVA.org:uu-398791DiVA, id: diva2:1377280
Available from: 2019-12-11 Created: 2019-12-11 Last updated: 2019-12-11Bibliographically approved

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