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Fight them or feed them: how the intestinal mucus layer manages the gut microbiota
Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, Bruna Stråket 16, University of Gothenburg, SE 413 45 Gothenburg, Sweden.ORCID iD: 0000-0002-6716-8284
2019 (English)In: Gastroenterology Report, ISSN 2052-0034, Vol. 7, no 1, p. 3-12Article in journal (Refereed) Published
Abstract [en]

The intestinal tract is inhabited by a tremendous number of microorganisms, termed the gut microbiota. These microorganisms live in a mutualistic relationship with their host and assist in the degradation of complex carbohydrates. Although the gut microbiota is generally considered beneficial, the vast number of microbial cells also form a permanent threat to the host. Thus, the intestinal epithelium is covered with a dense layer of mucus to prevent translocation of the gut microbiota into underlying tissues. Intestinal mucus is an organized glycoprotein network with a host-specific glycan structure. While the mucus layer has long been considered a passive, host-designed barrier, recent studies showed that maturation and function of the mucus layer are strongly influenced by the gut microbiota. In return, the glycan repertoire of mucins can select for distinct mucosa-associated bacteria that are able to bind or degrade specific mucin glycans as a nutrient source. Because the intestinal mucus layer is at the crucial interface between host and microbes, its breakdown leads to gut bacterial encroachment that can eventually cause inflammation and infection. Accordingly, a dysfunctional mucus layer has been observed in colitis in mice and humans. Moreover, the increased consumption of a low-fiber Western-style diet in our modern society has recently been demonstrated to cause bacteria-mediated defects of the intestinal mucus layer. Here, I will review current knowledge on the interaction between gut bacteria and the intestinal mucus layer in health and disease. Understanding the molecular details of this host-microbe interaction may contribute to the development of novel treatment options for diseases involving a dysfunctional mucus layer, such as ulcerative colitis.

Place, publisher, year, edition, pages
Oxford University Press, 2019. Vol. 7, no 1, p. 3-12
Keywords [en]
Dietary fiber, gut microbiota, host–microbe interaction, inflammatory bowel disease, metabolic disease, mucin, mucosal barrier, mucus, probiotics, ulcerative colitis
National Category
Gastroenterology and Hepatology Immunology Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-166016DOI: 10.1093/gastro/goy052ISI: 000467895100002PubMedID: 30792861OAI: oai:DiVA.org:umu-166016DiVA, id: diva2:1376356
Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2019-12-11Bibliographically approved

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