Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Symptom clusters in newly diagnosed glioma patients: which symptom clusters are independently associated with functioning and global health status?
Leiden Univ, Netherlands.
Leiden Univ, Netherlands; Haaglanden Med Ctr, Netherlands.
Netherlands Canc Inst, Netherlands.
Univ Hosp Bonn, Germany; Maastricht Univ, Netherlands; Maastricht Univ, Netherlands.
Show others and affiliations
2019 (English)In: Neuro-Oncology, ISSN 1522-8517, E-ISSN 1523-5866, Vol. 21, no 11, p. 1447-1457Article in journal (Refereed) Published
Abstract [en]

Background. Symptom management in glioma patients remains challenging, as patients suffer from various concurrently occurring symptoms. This study aimed to identify symptom clusters and examine the association between these symptom clusters and patients functioning. Methods. Data of the CODAGLIO project was used, including individual patient data from previously published international randomized controlled trials (RCTs) in glioma patients. Symptom prevalence and level of functioning were assessed with European Organisation for Research and Treatment of Cancer (EORTC) quality of life QLQ-C30 and QLQ-BN20 self-report questionnaires. Associations between symptoms were examined with Spearman correlation coefficients and partial correlation networks. Hierarchical cluster analyses were performed to identify symptom clusters. Multivariable regression analyses were performed to determine independent associations between the symptom clusters and functioning, adjusted for possible confounders. Results. Included in the analysis were 4307 newly diagnosed glioma patients from 11 RCTs who completed the EORTC questionnaires before randomization. Many patients (44%) suffered from 5-10 symptoms simultaneously. Four symptom clusters were identified: a motor cluster, a fatigue cluster, a pain cluster, and a gastrointestinal/seizures/bladder control cluster. Having symptoms in the motor cluster was associated with decreased (amp;gt;= 10 points difference) physical, role, and social functioning (betas ranged from -11.3 to -15.9, all P amp;lt; 0.001), independent of other factors. Similarly, having symptoms in the fatigue cluster was found to negatively influence role functioning (beta of -12.3, P amp;lt; 0.001), independent of other factors. Conclusions. Two symptom clusters, the fatigue and motor cluster, were frequently affected in glioma patients and were found to independently have a negative association with certain aspects of patients functioning as measured with a self-report questionnaire.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC , 2019. Vol. 21, no 11, p. 1447-1457
Keywords [en]
EORTC QLQ-C30; glioma; health-related quality of life; QLQ-BN20; symptom; symptom cluster
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-162542DOI: 10.1093/neuonc/noz118ISI: 000496767300014PubMedID: 31682733OAI: oai:DiVA.org:liu-162542DiVA, id: diva2:1376299
Note

Funding Agencies|EORTC Quality of Life Group

Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2020-01-22

Open Access in DiVA

fulltext(383 kB)15 downloads
File information
File name FULLTEXT01.pdfFile size 383 kBChecksum SHA-512
1db8a64399f236bbbce2976442d1edf375336b463cb70379ed3296b0e72cbe7a9ffb04d267068ad9f605f66105f3a6c0dbad158452fea78cf3ef3751a5601932
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Malmström, Annika
By organisation
Division of Cell BiologyFaculty of Medicine and Health SciencesDepartment of Advanced Home Care in Linköping
In the same journal
Neuro-Oncology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 15 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 17 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf