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Tumor angiogenesis: causes, consequences, challenges and opportunities
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.ORCID iD: 0000-0003-2685-0575
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.ORCID iD: 0000-0003-4422-9125
2019 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071Article in journal (Refereed) Epub ahead of print
Abstract [en]

Tumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur simultaneously within the same cancer tissue. These processes are orchestrated by a range of secreted factors and signaling pathways and can involve participation of non-endothelial cells, such as progenitors or cancer stem cells. Anti-angiogenic therapies using either antibodies or tyrosine kinase inhibitors have been approved to treat several types of cancer. However, the benefit of treatment has so far been modest, some patients not responding at all and others acquiring resistance. It is becoming increasingly clear that blocking tumors from accessing the circulation is not an easy task to accomplish. Tumor vessel functionality and gene expression often differ vastly when comparing different cancer subtypes, and vessel phenotype can be markedly heterogeneous within a single tumor. Here, we summarize the current understanding of cellular and molecular mechanisms involved in tumor angiogenesis and discuss challenges and opportunities associated with vascular targeting.

Place, publisher, year, edition, pages
Springer, 2019.
Keywords [en]
Angiogenesis, Cancer, Endothelial, Vascular targeting, VEGF, Anti-angiogenic therapy
National Category
Cell Biology Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-397923DOI: 10.1007/s00018-019-03351-7ISI: 000494382600001PubMedID: 31690961OAI: oai:DiVA.org:uu-397923DiVA, id: diva2:1376049
Funder
Swedish Cancer Society, CAN 2017/502Swedish Research Council, 2016-02495Swedish Cancer SocietySwedish Childhood Cancer Foundation, PR2018-0148Available from: 2019-12-06 Created: 2019-12-06 Last updated: 2019-12-06Bibliographically approved

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