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Mapping the landscape of human dopamine D2/3 receptors with [11C]raclopride
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
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2019 (English)In: Brain Structure and Function, ISSN 1863-2653, E-ISSN 1863-2661, Vol. 224, no 8, p. 2871-2882Article in journal (Refereed) Published
Abstract [en]

The dopamine D2/3 system is fundamental for sensory, motor, emotional, and cognitive aspects of behavior. Small-scale human histopathological and animal studies show high density of D2/3 dopamine receptors (D2/3DR) in striatum, but also demonstrate the existence of such receptors across cortical and limbic regions. Assessment of D2/3DR BPND in the extrastriatal regions with [C-11]raclopride has long been considered unreliable due to the relatively low density of D2/3DR outside the striatum. We describe the distribution and interregional links of D2/3DR availability measured with PET and [C-11]raclopride across the human brain in a large sample (N = 176; age range 64-68 years). Structural equation modeling revealed that D2/3DR availability can be organized according to anatomical (nigrostriatal, mesolimbic, mesocortical) and functional (limbic, associative, sensorimotor) dopamine pathways. D2/3DR availability in corticolimbic functional subdivisions showed differential associations to corresponding striatal subdivisions, extending animal and pharmacological work. Our findings provide evidence on the dimensionality and organization of [C-11]raclopride D2/3DR availability in the living human brain that conforms to known dopaminergic pathways.

Place, publisher, year, edition, pages
2019. Vol. 224, no 8, p. 2871-2882
Keywords [en]
[C-11]raclopride, Dopamine D2, 3 receptors, Inter-individual differences, Structural-equation deling, COBRA study
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-165669DOI: 10.1007/s00429-019-01938-1ISI: 000489147300018PubMedID: 31444615OAI: oai:DiVA.org:umu-165669DiVA, id: diva2:1375909
Available from: 2019-12-06 Created: 2019-12-06 Last updated: 2019-12-06Bibliographically approved

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Jonasson, Lars S.Karalija, NinaJohansson, JarkkoSalami, AlirezaAndersson, MicaelAxelsson, JanWåhlin, AndersRiklund, KatrineNyberg, Lars
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Umeå Centre for Functional Brain Imaging (UFBI)Department of Integrative Medical Biology (IMB)Department of Radiation SciencesWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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