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Cardiac Troponin T in Healthy Full-Term Infants
Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Sjukhusbacken 10, S-11883 Stockholm, Sweden;Sachs Childrens & Youth Hosp, Neonatal Unit, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden.ORCID iD: 0000-0002-5580-9187
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
Karolinska Inst, Dept Womens & Childrens Hlth, Widerstromska Huset,Tomtebodavagen 18A, S-17177 Stockholm, Sweden;Astrid Lindgrens Childrens Hosp, Pediat Cardiol Dept, Eugeniavagen 23, S-17164 Solna, Sweden.
Sachs Childrens & Youth Hosp, Neonatal Unit, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden;Karolinska Inst, Clin Epidemiol Div, S-17176 Stockholm, Sweden.
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2019 (English)In: Pediatric Cardiology, ISSN 0172-0643, E-ISSN 1432-1971, Vol. 40, no 8, p. 1645-1654Article in journal (Refereed) Published
Abstract [en]

In this prospective cohort study of healthy full-term infants, we hypothesized that high-sensitivity cardiac troponin T (hs-cTnT) would be elevated in cord blood, compared with adult reference values, and that it would further increase over the first days of age. Cardiac troponin T has been shown to be significantly increased in healthy full-term newborns compared with adult reference values, but there is no established reference range. Most studies of cTnT in newborns have been performed before the introduction of high-sensitivity cTnT (hs-cTnT) assay. We conducted a study including 158 full-term newborns, at Stockholm South General Hospital. High-sensitivity cTnT was analyzed in umbilical cord blood and at 2-5 days of age. Median hs-cTnT (interquartile range) in cord blood was 34(26-44) ng/L; 99th percentile 88 ng/L. Median hs-cTnT at 2-5 days of age was 92(54-158) ng/L; 99th percentile 664 ng/L. We conclude that hs-cTnT is elevated in cord blood in healthy, full-term newborn infants compared with adult reference values, and that it increases significantly during the first days of life. Our findings further underline the need of caution when using hs-cTnT as a measurement of cardiac impact in newborns.

Place, publisher, year, edition, pages
SPRINGER , 2019. Vol. 40, no 8, p. 1645-1654
Keywords [en]
Newborn, Cardiac troponin T, High-sensitivity cTnT
National Category
Pediatrics Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-398028DOI: 10.1007/s00246-019-02199-9ISI: 000495776000014PubMedID: 31489446OAI: oai:DiVA.org:uu-398028DiVA, id: diva2:1375767
Funder
Swedish Heart Lung Foundation, 20130469Available from: 2019-12-06 Created: 2019-12-06 Last updated: 2019-12-06Bibliographically approved

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