Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The risk of lymph node metastases and their impact on survival in patients with appendiceal neuroendocrine neoplasms: a systematic review and meta-analysis of adult and paediatric patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery. Univ Athens, Dept Propauped Internal Med 1, Endocrine Oncol Unit, Athens, Greece.ORCID iD: 0000-0003-4224-8912
Univ Athens, Dept Propauped Internal Med 1, Endocrine Oncol Unit, Athens, Greece.
Univ Athens, Dept Propauped Internal Med 1, Endocrine Oncol Unit, Athens, Greece;Univ Athens, Sch Med, Dept Biol Chem, Athens, Greece.
Univ Athens, Dept Propauped Internal Med 1, Endocrine Oncol Unit, Athens, Greece.
Show others and affiliations
2019 (English)In: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background There are no clear histopathological parameters determining the risk of lymph node (LN) metastases and appropriateness of completion prophylactic right hemicolectomy (RHC) in patients with appendiceal neuroendocrine neoplasms (ANENs). Materials and methods The PubMed, Cochrane Library, Embase, Web of Science and SCOPUS databases were searched up to November 2018. Quality/risk of bias was assessed using the Newcastle-Ottawa Scale (NOS). Results A total of 526 articles were screened. In 11 adult and 3 paediatric studies, 602 and 77 unique patients, respectively, with ANEN and undergoing RHC, were included. The rate of LN metastases for a cutoff size >10 mm was 48.6% (vs 12.1% for lesions <10 mm) among adult patients, with an odds ratio (OR) of 4.8 (95% CI, 1.5-15.8). For 20 mm size cutoff, these figures were 61% (vs 28.2% for lesions <20 mm) with an OR of 3.2 (95% CI, 1.3-7.8). Vascular-, lymph vessel- and perineural invasions were identified as predictive factors for LN metastases in adult patients. In paediatric patients, there were no strong morphological predictors for LN metastases. The 10-year disease-specific survival (DSS) for adult patients without LN metastases was 99.2% vs 95.6% in patients with LN (OR: 0.2; 95% CI, 0.02-2.4). The complication rate of prophylactic RHC was 11.4%. Conclusions This meta-analysis demonstrates that tumour size >20 mm as well as >10 mm and/or vascular-, lymph vessel- and perineural invasions are associated with increased risk for LN metastases in adult patients with ANEN. The prognostic value of LN positivity remains to be determined in further studies with long-term follow-up.

Place, publisher, year, edition, pages
Springer, 2019.
Keywords [en]
Appendiceal neuroendocrine neoplasms, Locoregional lymph node metastases, Prophylactic right hemicolectomy
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-397934DOI: 10.1007/s12020-019-02072-yISI: 000495192300002PubMedID: 31493274OAI: oai:DiVA.org:uu-397934DiVA, id: diva2:1375474
Funder
Swedish Society of MedicineAvailable from: 2019-12-05 Created: 2019-12-05 Last updated: 2019-12-05Bibliographically approved

Open Access in DiVA

fulltext(2540 kB)19 downloads
File information
File name FULLTEXT01.pdfFile size 2540 kBChecksum SHA-512
08a30782d2e97283d9b40d2ba2a7856fe9c44219ce50ff1e95a97e915d7346b1e6f846925110addc82c02c0b02bbb19cb08b4f004c9a6e9f343f26163a0b54ea
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Daskalakis, KosmasKaltsas, Gregory
By organisation
Endocrine Surgery
In the same journal
Endocrine (Basingstoke)
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 19 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 13 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf