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FoxB, a new and highly conserved key factor in arthropod dorsal-ventral (DV) limb patterning
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology. Lund Univ, Fac Sci, Dept Geol, Solvegatan 12, Lund, Sweden.
Georg August Univ, Abt Entwicklungsbiol, Johann Friedrich Blumenbach Inst Zool & Anthropol, Gottingen, Germany;Gottingen Ctr Mol Biosci GZMB, Ernst Caspari Haus, Gottingen, Germany.
Georg August Univ, Abt Entwicklungsbiol, Johann Friedrich Blumenbach Inst Zool & Anthropol, Gottingen, Germany;Justus Liebig Univ Giessen, Inst Allgemeine & Spezielle Zool, Bereich Allgemeine Zool & Entwicklungsbiol, Heinrich Buff Ring 38, D-35392 Giessen, Germany.
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
2019 (English)In: EvoDevo, ISSN 2041-9139, E-ISSN 2041-9139, Vol. 10, article id 28Article in journal (Refereed) Published
Abstract [en]

Forkhead box (Fox) transcription factors evolved early in animal evolution and represent important components of conserved gene regulatory networks (GRNs) during animal development. Most of the researches concerning Fox genes, however, are on vertebrates and only a relatively low number of studies investigate Fox gene function in invertebrates. In addition to this shortcoming, the focus of attention is often restricted to a few well-characterized Fox genes such as FoxA (forkhead), FoxC (crocodile) and FoxQ2. Although arthropods represent the largest and most diverse animal group, most other Fox genes have not been investigated in detail, not even in the arthropod model species Drosophila melanogaster. In a general gene expression pattern screen for panarthropod Fox genes including the red flour beetle Tribolium castaneum, the pill millipede Glomeris marginata, the common house spider Parasteatoda tepidariorum, and the velvet worm Euperipatoides kanangrensis, we identified a Fox gene with a highly conserved expression pattern along the ventral ectoderm of arthropod and onychophoran limbs. Functional investigation of FoxB in Parasteatoda reveals a hitherto unrecognized important function of FoxB upstream of wingless (wg) and decapentaplegic (dpp) in the GRN orchestrating dorsal-ventral limb patterning.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 10, article id 28
Keywords [en]
Appendage patterning, Forkhead domain, Limb segmentation, Development
National Category
Zoology Developmental Biology
Identifiers
URN: urn:nbn:se:uu:diva-398012DOI: 10.1186/s13227-019-0141-6ISI: 000495651900001PubMedID: 31728178OAI: oai:DiVA.org:uu-398012DiVA, id: diva2:1375259
Funder
Swedish Research Council, 621-2011-4703German Research Foundation (DFG), PR 1109/4-1German Research Foundation (DFG), PR 1109/6-1Available from: 2019-12-04 Created: 2019-12-04 Last updated: 2019-12-04Bibliographically approved

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