Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis: a prospective longitudinal inception cohort study
Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden.
Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden.ORCID iD: 0000-0001-7675-3488
Umea Univ, Dept Stat, Umea, Sweden.
Karolinska Inst, Dept Rheumatol, Stockholm, Sweden.
Show others and affiliations
2019 (English)In: RMD Open, E-ISSN 2056-5933, Vol. 5, no 2, article id e000946Article in journal (Refereed) Published
Abstract [en]

Introduction: Anticitrullinated peptide antibody (ACPA) responses for 22 citrullinated peptides in patients with early rheumatoid arthritis (RA) were analysed and related to radiological and clinical outcome during the first 2 years in a prospective inception cohort.

Methods: The ACPA reactivities were assessed in 1022 patients with early RA (symptoms <12 months) using the custom-made microarray chip (Thermo Fisher Scientific, Uppsala, Sweden) in a prospective longitudinal study of observational assessments of Disease Activity Score (DAS28 and its components) and radiology during the first 24 months, accounting for the treatment.

Results: Frequency of ACPA reactivities varied between 13.3% and 63.1%. Of the anticyclic citrullinated peptide-2 (anti-CCP2) antibody-negative patients, ACPA reactivities were positive in 32.6%. Smoking, human leucocyte antigen-shared epitope ( HLA-SE), anti-CCP2/rheumatoid factor, protein tyrosine phosphatase nonreceptor type 22 (1858C/ T) and DAS28 were significantly associated with number of ACPA reactivities. The ACPA reactivities modified differently the development of DAS28 over 24 months (identified using trajectories). Anti-Filaggrin307-324, anti-hnRNP (Peptide)-Z1 and anti-F4-CIT-R antibodies anticipated lower DAS28 values (p<0.01-0.05), while positivity for anti-Fibrinogen(Fib) beta 62-78(74), and anti-Fiba563-583 predicted higher DAS28 (p<0.01 both). Interaction between anti-Fib beta 36-52, anti-Pept-5 and anti-Bla-26 antibodies, respectively, and DAS28 during 24 months decreased significantly the DAS28 values (p<0.01-0.05). Corticosteroids and biologicals were related to DAS28-area under the curve and Larsen score 24 months. Anti-vimentin2-17 antibodies remained significantly associated with Larsen score at baseline and 24 months, respectively, and radiological progression, besides biologicals at 24 months adjusted for sex and age.

Conclusions: Several ACPA reactivities modified significantly the DAS28 development during the first 24 months and were significantly associated with Larsen score at baseline, 24 months and radiological progression.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2019. Vol. 5, no 2, article id e000946
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-398011DOI: 10.1136/rmdopen-2019-000946ISI: 000496133800042PubMedID: 31565241OAI: oai:DiVA.org:uu-398011DiVA, id: diva2:1375254
Funder
Swedish Research Council, K2013-52X-2030707-3Swedish Research Council, Dnr:2018-02551Swedish Rheumatism AssociationAvailable from: 2019-12-04 Created: 2019-12-04 Last updated: 2019-12-04Bibliographically approved

Open Access in DiVA

fulltext(519 kB)13 downloads
File information
File name FULLTEXT01.pdfFile size 519 kBChecksum SHA-512
ebcdbe2c15b3f4f1a0e5aeeee3e2f878b0a3c52951191099a10c89d178d9023275c6d6ce4bab81e149f669c5bf392f4163c8d843d94f7d32e087dfa4c0b4146c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Brink, MikaelMathsson Alm, LindaRönnelid, JohanHolmdahl, Rikard
By organisation
Clinical Immunology
In the same journal
RMD Open
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar
Total: 13 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf