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In-situ time resolved spectrographic measurement using an additively manufactured metallic micro-fluidic analysis platform
Ministry of Defence Abbey Wood, Bristol, United Kingdom.
School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland.
Department of Chemistry, Loughborough University, Loughborough, United Kingdom.
Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), Centre for Research on Embedded Systems (CERES).ORCID iD: 0000-0002-0480-4079
2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 11, article id e0224492Article in journal (Refereed) Published
Abstract [en]

Introduction

Microfluidic reactionware allows small volumes of reagents to be utilized for highly controlled flow chemistry applications. By integrating these microreactors with onboard analytical systems, the devices change from passive ones to active ones, increasing their functionality and usefulness. A pressing application for these active microreactors is the monitoring of reaction progress and intermediaries with respect to time, shedding light on important information about these real-time synthetic processes.

Objective

In this multi-disciplinary study the objective was to utilise advanced digital fabrication to research metallic, active microreactors with integrated fibre optics for reaction progress monitoring of solvent based liquids, incompatible with previously researched polymer devices, in combination with on-board Ultraviolet-visible spectroscopy for real-time reaction monitoring.

Method

A solid-state, metal-based additive manufactured system (Ultrasonic Additive Manufacturing) combined with focussed ion beam milling, that permitted the accurate embedment of delicate sensory elements directly at the point of need within aluminium layers, was researched as a method to create active, metallic, flow reactors with on-board sensing. This outcome was then used to characterise and correctly identify concentrations of UV-active water-soluble B-vitamin nicotinamide and fluorescein. A dilution series was formed from 0.01–1.75 mM; which was pumped through the research device and monitored using UV-vis spectroscopy.

Results

The results uniquely showed the in-situ ion milling of ultrasonically embedded optical fibres resulted in a metallic microfluidic reaction and monitoring device capable of measuring solvent solutions from 18 μM to 18 mM of nicotinamide and fluorescein, in real time. This level of accuracy highlights that the researched device and methods are capable of real-time spectrographic analysis of a range of chemical reactions outside of those possible with polymer devices.

Place, publisher, year, edition, pages
San Francisco, CA: Public Library of Science , 2019. Vol. 14, no 11, article id e0224492
Keywords [en]
Microfluidics, 3D Printing, Spectroscopy, Optical Fibre
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:hh:diva-41041DOI: 10.1371/journal.pone.0224492OAI: oai:DiVA.org:hh-41041DiVA, id: diva2:1373485
Available from: 2019-11-27 Created: 2019-11-27 Last updated: 2019-11-27Bibliographically approved

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