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Light-Induced Dimerization Approaches to Control Cellular Processes
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
2019 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 25, p. 12452-12463Article in journal (Refereed) Published
Abstract [en]

Light-inducible approaches provide a means to control biological systems with spatial and temporal resolution that is unmatched by traditional genetic perturbations. Recent developments of optogenetic and chemo-optogenetic systems for induced proximity in cells facilitate rapid and reversible manipulation of highly dynamic cellular processes and have become valuable tools in diverse biological applications. New expansions of the toolbox facilitate control of signal transduction, genome editing, "painting" patterns of active molecules onto cellular membranes, and light-induced cell cycle control. A combination of light- and chemically induced dimerization approaches have also seen interesting progress. Herein, an overview of optogenetic systems and emerging chemo-optogenetic systems is provided, and recent applications in tackling complex biological problems are discussed.

Place, publisher, year, edition, pages
2019. Vol. 25, p. 12452-12463
Keywords [en]
chemo-optogenetics, dimerization, optogenetics, photochemistry, proteins
National Category
Organic Chemistry Biochemistry and Molecular Biology Cell Biology
Identifiers
URN: urn:nbn:se:umu:diva-165585DOI: 10.1002/chem.201900562ISI: 000487749300001PubMedID: 31304989OAI: oai:DiVA.org:umu-165585DiVA, id: diva2:1373410
Available from: 2019-11-27 Created: 2019-11-27 Last updated: 2019-11-28Bibliographically approved

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