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Celiac disease and complement activation in response to Streptococcus pneumoniae
Kalmar Cty Hosp, Dept Pediat, Kalmar, Sweden; Örebro Univ, Sch Med Sci, Örebro, Sweden.
Kalmar Cty Hosp, Dept Dev & Publ Hlth, Res Sect, Kalmar, Sweden.
Linnaeus Univ, Linnaeus Ctr Biomat Chem, Kalmar, Sweden.
Kalmar Cty Hosp, Dept Clin Microbiol, Kalmar, Sweden; Linköping Univ, Dept Clin & Expt Med, Linköping, Sweden.
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2019 (English)In: European Journal of Pediatrics, ISSN 0340-6199, E-ISSN 1432-1076Article in journal (Refereed) Published
Abstract [en]

Individuals with celiac disease (CD) are at increased risk of invasive pneumococcal disease (IPD). The aim of this study was to explore whether the complement response to Streptococcus pneumoniae differed according to CD status, and could serve as an explanation for the excess risk of IPD in CD. Twenty-two children with CD and 18 controls, born 1999–2008, were included at Kalmar County Hospital, Sweden. The degree of complement activation was evaluated by comparing levels of activation products C3a and sC5b-9 in plasma incubated for 30 min with Streptococcus pneumoniae and in non-incubated plasma. Complement analyses were performed with enzyme-linked immunosorbent assay (ELISA). Pneumococcal stimulation caused a statistically significant increase in C3a as well as sC5b-9 in both children with CD and controls but there was no difference in response between the groups. After incubation, C3a increased on average 4.6 times and sC5b-9 22 times in both the CD and the control group (p = 0.497 and p = 0.724 respectively).

Conclusion: Complement response to Streptococcus pneumoniae seems to be similar in children with and without CD and is thus unlikely to contribute to the increased susceptibility to invasive pneumococcal disease in CD.

Place, publisher, year, edition, pages
2019.
Keywords [en]
Coeliac, Pneumococcal, Infection, Innate immunity, MBL
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-397648DOI: 10.1007/s00431-019-03490-wISI: 000494392200001PubMedID: 31691001OAI: oai:DiVA.org:uu-397648DiVA, id: diva2:1373199
Funder
Swedish Research Council, 522-2A09-195Swedish Research Council, 2016-2075-5.1Swedish Research Council, 2018-04087The Research Council of Norway, 274332
Note

Early access: Article that have been peer-reviewed and accepted for publication. The article content has been finalized, but it has not been assigned to an issue yet.

Available from: 2019-11-26 Created: 2019-11-26 Last updated: 2019-11-26Bibliographically approved

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