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Memory profiles predict dementia over 23–28 years in normal but not successful aging
Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR). Demographic Data Base. (Maria Josefsson)ORCID iD: 0000-0002-1812-3581
Umeå University, Faculty of Social Sciences, Department of Psychology. Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2019 (English)In: International psychogeriatrics, ISSN 1041-6102, E-ISSN 1741-203XArticle in journal (Refereed) Epub ahead of print
Abstract [en]

Objectives: Prospective studies suggest that memory deficits are detectable decades before clinical symptoms of dementia emerge. However, individual differences in long-term memory trajectories prior to diagnosis need to be further elucidated. The aim of the current study was to investigate long-term dementia and mortality risk for individuals with different memory trajectory profiles in a well-characterized population-based sample.

Methods: 1062 adults (aged 45–80 years) who were non-demented at baseline were followed over 23–28 years. Dementia and mortality risk were studied for three previously classified episodic memory trajectory groups: maintained high performance (Maintainers; 26%), average decline (Averages; 64%), and accelerated decline (Decliners; 12%), using multistate modeling to characterize individuals’ transitions from an initial non-demented state, possibly to a state of dementia and/or death.

Results: The memory groups showed considerable intergroup variability in memory profiles, starting 10–15 years prior to dementia diagnosis, and prior to death. A strong relationship between memory trajectory group and dementia risk was found. Specifically, Decliners had more than a fourfold risk of developing dementia compared to Averages. In contrast, Maintainers had a 2.6 times decreased dementia risk compared to Averages, and in addition showed no detectable memory decline prior to dementia diagnosis. A similar pattern of association was found for the memory groups and mortality risk, although only among non-demented.

Conclusion: There was a strong relationship between accelerated memory decline and dementia, further supporting the prognostic value of memory decline. The intergroup differences, however, suggest that mechanisms involved in successful memory aging may delay symptom onset.

Place, publisher, year, edition, pages
Cambridge University Press, 2019.
Keywords [en]
memory decline, episodic memory, death, competing risk, multistate model
National Category
Psychology (excluding Applied Psychology)
Identifiers
URN: urn:nbn:se:umu:diva-165499DOI: 10.1017/S1041610219001844PubMedID: 31762427OAI: oai:DiVA.org:umu-165499DiVA, id: diva2:1372783
Available from: 2019-11-25 Created: 2019-11-25 Last updated: 2019-11-26

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Josefsson, MariaSundström, AnnaPudas, SaraNordin Adolfsson, AnnelieNyberg, LarsAdolfsson, Rolf
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Centre for Demographic and Ageing Research (CEDAR)Department of PsychologyDepartment of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)PsychiatryDepartment of Radiation Sciences
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