Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
RIKEN Yokohama Inst, Ctr Integrat Med Sci, Lab Mucosal Immun, Suehirocho,1 Chome 7-22, Yokohama, Kanagawa 2300045, Japan.
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
Show others and affiliations
2019 (English)In: ISCIENCE, ISSN 2589-0042, Vol. 20, p. 359-+Article in journal (Refereed) Published
Abstract [en]

Monoamine neurotransmitters are released by specialized neurons regulating behavioral, motor, and cognitive functions. Although the localization of monoaminergic neurons in the brain is well known, the distribution and kinetics of monoamines remain unclear. Here, we generated a murine brain atlas of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) levels using mass spectrometry imaging (MSI). We found several nuclei rich in both 5-HT and a catecholamine (DA or NE) and identified the paraventricular nucleus of the thalamus (PVT), where 5-HT and NE are co-localized. The analysis of 5-HT fluctuations in response to acute tryptophan depletion and infusion of isotope-labeled tryptophan in vivo revealed a close kinetic association between the raphe nuclei, PVT, and amygdala but not the other nuclei. Our findings imply the existence of a highly dynamic 5-HT-mediated raphe to PVT pathway that likely plays a role in the brain monoamine system.

Place, publisher, year, edition, pages
CELL PRESS , 2019. Vol. 20, p. 359-+
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:uu:diva-397301DOI: 10.1016/j.isci.2019.09.036ISI: 000493388000028PubMedID: 31614319OAI: oai:DiVA.org:uu-397301DiVA, id: diva2:1372749
Funder
Swedish Research Council, 2018-03320Swedish Research Council, 2018-05501Available from: 2019-11-25 Created: 2019-11-25 Last updated: 2019-11-25Bibliographically approved

Open Access in DiVA

fulltext(6156 kB)7 downloads
File information
File name FULLTEXT01.pdfFile size 6156 kBChecksum SHA-512
25d16e3bdbdbdff3be74749b17d80c01d05434ef40354c38996dd92968a9e864eb706a2238b4ff89cb45ba0edeea787f4f19adaeb7cb1544f5e365569e77d257
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Källback, PatrikAndrén, Per E.
By organisation
Department of Pharmaceutical BiosciencesScience for Life Laboratory, SciLifeLab
NeurosciencesNeurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 7 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf