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Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum
Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden; Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.
Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden; Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics. Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden; Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.
Univ Calif Davis, NIH West Coast Metabol Ctr, Genome Ctr, Davis, CA 95616 USA.
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2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 15385Article in journal (Refereed) Published
Abstract [en]

The search for biomarkers associated with obesity-related diseases is ongoing, but it is not clear whether plasma and serum can be used interchangeably in this process. Here we used high-throughput screening to analyze 358 proteins and 76 lipids, selected because of their relevance to obesity-associated diseases, in plasma and serum from age- and sex-matched lean and obese humans. Most of the proteins/lipids had similar concentrations in plasma and serum, but a subset showed significant differences. Notably, a key marker of cardiovascular disease PAI-1 showed a difference in concentration between the obese and lean groups only in plasma. Furthermore, some biomarkers showed poor correlations between plasma and serum, including PCSK9, an important regulator of cholesterol homeostasis. Collectively, our results show that the choice of biofluid may impact study outcome when screening for obesity-related biomarkers and we identify several markers where this will be the case.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 9, article id 15385
National Category
Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:uu:diva-397416DOI: 10.1038/s41598-019-51673-0ISI: 000492832000003PubMedID: 31659186OAI: oai:DiVA.org:uu-397416DiVA, id: diva2:1371614
Funder
Knut and Alice Wallenberg FoundationSwedish Research Council, 2016/82EU, European Research Council, 804418Swedish Heart Lung Foundation, HL128457Swedish Heart Lung Foundation, HL107744Swedish Heart Lung Foundation, 20180199Swedish Society for Medical Research (SSMF), S150086Åke Wiberg Foundation, M15-0058Available from: 2019-11-20 Created: 2019-11-20 Last updated: 2019-11-20Bibliographically approved

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